Anti-HPV-16 L1, clone rHPV16L1/1058

Anti-HPV-16 L1, clone rHPV16L1/1058
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3659SAF-100UG 100 µg - -

3 - 10 business days*

752.00€
 
1 mg/ml in 1X PBS, BSA free, sodium azide free. Reacts with a protein of 57kDa, identified as the... more
Product information "Anti-HPV-16 L1, clone rHPV16L1/1058"
1 mg/ml in 1X PBS, BSA free, sodium azide free. Reacts with a protein of 57kDa, identified as the L1 protein of human papilloma virus type 16 (HPV-16). It is the major capsid protein of HPV-16. Infection with specific types of HPV has been associated with an increased risk of developing cervical neoplasia. HPV types 6 and 11 have been associated with relatively benign diseases such as genital warts but types 16 and 18 are strongly associated with cervical, vaginal, and vulvar malignancies. The antibody reacts very strongly with formalin-fixed, paraffin-embedded tissues containing HPV-16 or -33, very weak reactions were occasionally observed with biopsy specimens or smears containing HPV-6 or HPV-11. It cross-reacts with HPV37. Protein function: Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2. [The UniProt Consortium]
Keywords: Anti-Major capsid protein L1, HPV-16 L1 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V3659SAF

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: rHPV16L1/1058
Conjugate: No
Host: Mouse
Species reactivity: type 16 of human papilloma virus (hpv-16)
Immunogen: Human papilloma virus type 16, major capsid protein L1, was used as the immunogen for the recombinant HPV16 L1 antibody.
Format: Purified

Database Information

UniProt ID : P03101 | Matching products

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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