Anti-Histone H4R3Me2s Rabbit (Clone RM459)

Histone H4 is one of four core histone proteins that are involved in the organization of DNA into chromatin. Histones are globular proteins with unstructured N-terminal tails and are subject to a variety of posttranslational modifications, such as methylation, acetylation, phosphorylation, and citrullination, that can influence chromatin structure and regulate gene transcription. Histone H4 symmetrical dimethylation at arginine 3 (H4R3Me2s) is regulated by protein arginine methyltransferase 5 (PRMT5) and PR domain zinc finger protein 4 (PRDM4). H4R3Me2s is enriched and associated with gene repression and cell growth in BGC-823 and SGC-7901 gastric cancer cells. Suppression of symmetrical dimethylation of H4R3 is associated with cardiomyocyte hypertrophy. Cayman's Histone H4R3Me2s Monoclonal Antibody (Clone RM459) can be used for multiplex-based assay and Western blot (WB) applications.. Cross reactivity: (+) H4R3Me2s: (-) H4R3, (-) H4R3Me1, (-) H4R3Me2a, (-) H3R2Me1, (-) H3R2Me2a, (-) H3R2Me2s, (-) H3R8Me1, (-) H3R8Me2a, (-) H3R8Me2s. (+) Human: (+) Vertebrates.. Protein function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [The UniProt Consortium]