Anti-Histone H2A.X

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-70233.60 60 µl -

7 - 16 business days*

158.00€
E-AB-70233.120 120 µl -

7 - 16 business days*

257.00€
E-AB-70233.200 200 µl -

7 - 16 business days*

406.00€
 
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the... more
Product information "Anti-Histone H2A.X"
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. Protein function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation. [The UniProt Consortium]
Keywords: Anti-H2AX, Anti-H2a/x, Anti-H2AFX, Anti-Histone H2AX, Anti-Histone H2A.X, Histone H2A.X Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-70233

Properties

Application: WB, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Histone H2A.X

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-Histone H2A.X"
Write a review
or to review a product.
Viewed