Anti-HDAC1, clone SQab1867

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG66319.100 100 µl - -

6 - 14 business days*

624.00€
 
Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of... more
Product information "Anti-HDAC1, clone SQab1867"

Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation. [The UniProt Consortium]

Keywords: Anti-HD1, Anti-RPD3L1, EC=3.5.1.98, Anti-Histone deacetylase 1
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG66319

Properties

Application: FC, ICC, IF, IHC (paraffin), WB
Antibody Type: Monoclonal
Clone: SQab1867
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Synthetic peptide around the C-terminus of HDAC1
MW: 55 kD
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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