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Trichostatin A
Trichostatin A

Item number: AG-CN2-0108-M001

Antibiotic, antifungal, antiprotozoal, potent and reversible, cell permeable inhibitor of histone deacetylase (HDAC), immunosuppressive, anticancer compound, antifibrogenic, apoptosis inducer, induces cell growth arrest at both G1 and G2/M phases, enhances the efficacy of anticancer agents that target DNA,...
Keywords: TSA, A300, R-(E,E)-7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide
Application: Apoptosis Inducer
CAS 58880-19-6
MW: 302,4 D
From 99.00€ *
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SAHA
SAHA

Item number: Cay10009929-1

SAHA is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. It inhibits class I, II, and IV HDACs at 50-200 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.
Keywords: Suberoylanilide Hydroxamic Acid, Vorinostat, N1-hydroxy-N8-phenyl-octanediamide
Application: HDAC inhibitor
CAS 149647-78-9
MW: 264.3 D
From 24.00€ *
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Sodium 4-Phenylbutyrate
Sodium 4-Phenylbutyrate

Item number: Cay11323-1

Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins. It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors. Formulations containing sodium...
Keywords: Benzenebutanoic acid, NSC 657802, TriButyrate, benzenebutanoic acid, monosodium salt
Application: Chemical chaperone, HDAC inhibitor
CAS 1716-12-7
MW: 186.2 D
From 44.00€ *
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MS-275
MS-275

Item number: Cay13284-1

MS-275 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 µM). However, it does not inhibit HDAC8 (IC50 > 100 µM). MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in...
Keywords: Entinostat, SNDX 275, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-3-pyridinylmethyl ester, carbamic acid
Application: HDAC inhibitor
CAS 209783-80-2
MW: 376.4 D
From 20.00€ *
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Trichostatin A
Trichostatin A

Item number: Cay89730-1

Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM. Trichostatin A selectively inhibits the removal of acetyl groups from the...
Keywords: TSA, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide
Application: HDAC inhibitor
CAS 58880-19-6
MW: 302.4 D
From 63.00€ *
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Valproic Acid (sodium salt)
Valproic Acid (sodium salt)

Item number: Cay13033-10

Valproic acid is an analog of the natural fatty acid valeric acid that inhibits class I histone deacetylases (HDACs) with an IC50 value of approximately 2 mM. It decreases the number of axon branches in sensory neurons isolated from newborn rat dorsal root ganglia, an effect that is reversed by...
Keywords: 2-Propylvaleric Acid, Sodium Valproate, 2-propyl-pentanoic acid, monosodium salt
Application: HDAC inhibitor
CAS 1069-66-5
MW: 166.2 D
From 34.00€ *
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Anti-HDAC2
Anti-HDAC2

Item number: A300-705A

Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone...
Keywords: Anti-HD2, Anti-HDAC2, EC=3.5.1.98, Anti-Histone deacetylase 2
Application: WB, IP, IHC, ChIP-Seq
Reactivity: Human, Mouse
From 125.00€ *
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Anti-HDAC1
Anti-HDAC1

Item number: A300-713A

Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone...
Keywords: Anti-HD1, Anti-HDAC1, Anti-RPD3L1, EC=3.5.1.98, Anti-Histone deacetylase 1
Application: WB, IP, IHC
Reactivity: Human, Mouse
From 125.00€ *
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HDAC-2, active human recombinant protein, His Tag
HDAC-2, active human recombinant protein, His Tag

Item number: BPS-50002

Active human HDAC2 , GenBank Accession No. Q92769, full length with C-terminal His tag, MW= 60 kDa, expressed in baculovirus expression system.
Keywords: Histone Deacetylase-2, HDAC2 HD2, HDAC2, EC=3.5.1.98, Histone deacetylase 2
Application: Enzyme kinetics, inhibitor screening
MW: 60 kD
556.00€ *
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HDAC-1, active human recombinant protein
HDAC-1, active human recombinant protein

Item number: BPS-50051

Active human HDAC1, GenBank Accession No. NM_004964, full length with C-terminal HIS-DDDDK tag (FLAG), MW= 56 kDa, expressed in baculovirus expression system.
Keywords: Histone Deacetylase-1, HDAC1 HD1, HDAC1, RPD3L1, EC=3.5.1.98, Histone deacetylase 1
Application: Enzyme kinetics, inhibitor screening
MW: 56 kD
556.00€ *
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HDAC Fluorometric Activity Assay Kit
HDAC Fluorometric Activity Assay Kit

Item number: Cay10011563-96

Histone deacetylases (HDACs) catalyze the hydrolytic removal of acetyl groups from histone lysine residues resulting in chromatin condensation and transcriptional repression of chromosomal DNA. Thus, HDAC inhibition allows the conformation of DNA to be relaxed and transcriptional activation to ensue. Transcriptional...
Keywords: Histone Deacetylase, HD1, HDAC1, RPD3L1, EC=3.5.1.98, Histone deacetylase 1
Application: HDAC activity measurement
350.00€ *
Review
HDAC1 Inhibitor Screening Assay Kit
HDAC1 Inhibitor Screening Assay Kit

Item number: Cay10011564-96

Histone deacetylases (HDACs) catalyze the hydrolytic removal of acetyl groups from histone lysine residues resulting in chromatin condensation and transcriptional repression of chromosomal DNA. Thus, HDAC inhibition allows the conformation of DNA to be relaxed and transcriptional activation to ensue. Changes in the...
Keywords: HD1, HDAC1, RPD3L1, EC=3.5.1.98, Histone deacetylase 1
Application: HDAC1 inhibitor screening
Reactivity: Human
375.00€ *
Review
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