Anti-gp100 Cocktail (PMEL17), clone HMB45 + PMEL/783

Anti-gp100 Cocktail (PMEL17), clone HMB45 + PMEL/783
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2857SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. By immunohistochemistry, it specifically... more
Product information "Anti-gp100 Cocktail (PMEL17), clone HMB45 + PMEL/783"
1 mg/ml in sterile PBS, BSA free, sodium azide free. By immunohistochemistry, it specifically recognizes a protein in melanocytes and melanomas. This mAb reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes. Intradermal nevi, normal adult melanocytes, and non-melanocytic cells are negative. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas, large cell lymphomas, and sarcomas using H & E stains alone. It is also difficult to differentiate melanoma from spindle cell carcinomas and various types of mesenchymal neoplasms. This mAb stains fetal and neonatal melanocytes, junctional and blue nevus cells, and malignant melanoma. This mAb also stains Angiomyolipoma (PEComa). Protein function: Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. [The UniProt Consortium]
Keywords: Anti-PMEL, Anti-D12S53E, gp100 Antibody Cocktail (PMEL17)
Supplier: NSJ Bioreagents
Supplier-Nr: V2857SAF-100UG

Properties

Application: FC, IF, IHC (paraffin)
Antibody Type: Mixed
Clone: HMB45+PMEL/783
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Extract of pigmented melanoma metastases from lymph nodes (HMB45), Recombinant human SILV/gp100 protein (PMEL/783)
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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