Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-843A-T 20 µl (2 blots) -

3 - 9 business days*

A301-843A-M 100 µl (10 blots) -

3 - 9 business days*

A301-843A 100 µl (20 µg) -

3 - 9 business days*

Protein function: Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in... more
Product information "Anti-GCN1L1"
Protein function: Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes, during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA- binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. [The UniProt Consortium]
Keywords: Anti-HsGCN1, Anti-GCN1-like protein 1, Anti-Translational activator GCN1, Anti-eIF-2-alpha kinase activator GCN1, Anti-GCN1 eIF-2-alpha kinase activator homolog, Anti-General control of amino-acid synthesis 1-like protein 1
Supplier: Bethyl Laboratories
Supplier-Nr: A301-843A


Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat (Expected: Bovine, Horse, Rabbit, Pig, Gorilla, Chimpanzee, White-tufted-ear Marmoset, African Elephant, Naked Mole Rat, Thirteen-lined Ground Squirrel, Little Brown Bat, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A301-843A-T maps to a region between residue 2621 and 2671 of human general control of amino-acid synthesis 1-like 1 using the numbering given in entry NP_006827.1 (GeneID 10985).
Format: Antigen Affinity Purified

Database Information

UniProt ID : Q92616 | Find alternatives
Gene ID GeneID 10985 | Find alternatives

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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