Anti-GCN1L1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A301-843A-T	10 µl (2 µg)		-		2 - 8 business days*		164.00€
A301-843A	100 µl		-		2 - 8 business days*		588.00€

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Protein function: Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in... more

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Product information "Anti-GCN1L1"

Protein function: Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes, during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA- binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. [The UniProt Consortium]

Keywords:	Anti-HsGCN1, Anti-GCN1-like protein 1, Anti-Translational activator GCN1, Anti-eIF-2-alpha kinase activator GCN1, Anti-GCN1 eIF-2-alpha kinase activator homolog, Anti-General control of amino-acid synthesis 1-like protein 1
Supplier:	Bethyl Laboratories
Supplier-Nr:	A301-843A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat (Expected: bovine, horse, rabbit, pig, gorilla, chimpanzee, white-tufted-ear marmoset, african elephant, naked mole rat, thirteen-lined ground squirrel, little brown bat, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A301-843A-T maps to a region between residue 2621 and 2671 of human general control of amino-acid synthesis 1-like 1 using the numbering given in entry NP_006827.1 (GeneID 10985).
Format:	Antigen Affinity Purified