Anti-GABBR2 / GABA-B receptor 2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. GABBR2 antibody recognizes gamma-aminobutyric acid type B receptor subunit 2, a critical component of the GABA-B receptor complex that mediates inhibitory neurotransmission in the central nervous system. The GABA-B receptor is a G-protein-coupled receptor (GPCR) that functions as an obligate heterodimer composed of GABBR1 and GABBR2 subunits. While GABBR1 primarily binds the neurotransmitter GABA, GABBR2 is essential for G-protein coupling and signal transduction. Together, they regulate synaptic transmission, neuronal excitability, and plasticity by modulating calcium and potassium channels. The GABBR2 antibody is widely used in neuroscience research to study receptor distribution, intracellular trafficking, and synaptic physiology, as well as in models of epilepsy, addiction, and neurodegeneration.GABBR2 is a transmembrane protein encoded by the GABBR2 gene, located on human chromosome 9q22.33. It contains a large extracellular Venus flytrap domain, a seven-transmembrane GPCR domain, and a long cytoplasmic tail involved in receptor assembly and signaling. The interaction of GABBR2 with GABBR1 is required for proper receptor localization at the cell surface. Dysregulation or mutations in GABBR2 have been associated with neurodevelopmental disorders, such as Rett-like syndrome and epileptic encephalopathy, emphasizing its importance in synaptic regulation. Experimental models have shown that altered GABA-B receptor function contributes to impaired inhibitory signaling and enhanced neuronal hyperexcitability.The GABBR2 antibody is particularly valuable in immunohistochemistry for mapping GABA-B receptor expression across different brain regions, including the hippocampus, cortex, cerebellum, and spinal cord. Western blot analysis using this antibody often reveals bands around 100-110 kDa, corresponding to the mature receptor subunit. It is also useful in co-immunoprecipitation studies to confirm receptor dimerization with GABBR1 and interaction with downstream signaling molecules such as G-proteins and adenylate cyclases. Because of its high specificity and reproducibility, this antibody has become a standard reagent for characterizing the molecular and cellular mechanisms of inhibitory neurotransmission. NSJ Bioreagents provides a validated reagent that supports diverse applications including immunofluorescence and confocal microscopy to visualize receptor localization at synapses.Research into GABBR2 continues to illuminate its roles beyond classical neurotransmission. Studies have linked GABA-B receptor signaling to cognitive flexibility, mood regulation, and drug dependence. Pharmacological modulation of this receptor has shown promise in treating anxiety, spasticity, and addiction disorders. The availability of a reliable GABBR2 antibody facilitates continued exploration into the receptor's signaling mechanisms, post-translational modifications, and potential therapeutic targets in neurological and psychiatric diseases.