Anti-GABAA Receptor beta2 Subunit

GABAA receptors are ligand-gated chloride channels that mediate the effects of the inhibitory neurotransmitter GABA in the CNS. They are postsynaptic heteropentameric receptors that contain protein subunits from the following isoforms: alpha1-6, beta1-4, gamma1-3, delta, epsilon, pi, theta, and rho1-3, arranged around a central pore. Phasic inhibitory synaptic transmission is regulated by alpha1beta2gamma2 subunit-containing GABAA receptors, the major isoform found in the brain. The beta subunit of GABAA receptors interfaces with an alpha subunit to form the GABA binding site that initiates GABA-induced action potentials and forms the benzodiazepine binding site with the gamma subunit. Phosphorylation of the beta2 subunit by PKC inhibits binding of the beta2 subunit with the clathrin adaptor protein AP2 and reduces GABAA receptor endocytosis. SNPs in GABRB2, which encodes the beta2 subunit isoform, have been found in patients with schizophrenia. Cayman's GABAA Receptor beta2 Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes the GABAA receptor beta2 subunit at approximately 55 kDa from mouse and rat samples.Synonyms: GABAA Receptor Subunit beta2, GABRB2, Gamma-aminobutyric Acid (GABA) A Receptor, beta2, Gamma-aminobutyric Acid Receptor Subunit beta2. Immunogen: Fusion protein from the cytoplasmic loop of the beta2 subunit of the rat GABAA receptor. MW: ~55 kDa. Formulation: (Request formulation change), 100 µl of affinity-purified rabbit polyclonal antibody. Storage Buffer: 10 mM HEPES, pH 7.5, with 150 mM sodium chloride, 100 µg/ml BSA, and 50% glycerol. Host: Rabbit. Applications: WB.