Anti-FBXW7 (R479L)

Anti-FBXW7 (R479L)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NB-26347 100 µl - -

2 - 16 business days

614.00€
 
Concentration: 1 mg/ml Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50%... more
Product information "Anti-FBXW7 (R479L)"
Concentration: 1 mg/ml Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Protein function: Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). [The UniProt Consortium]
Keywords: Anti-hAgo, Anti-hCdc4, Anti-SEL-10, Anti-F-box protein FBX30, Anti-Archipelago homolog, Anti-F-box/WD repeat-containing protein 7, Anti-F-box and WD-40 domain-containing protein 7, mutation-specific Delta (Arg479Leu)
Supplier: NewEast Biosciences
Supplier-Nr: 26347

Properties

Application: ELISA, WB, IHC
Antibody Type: Monoclonal
Conjugate: No
Host: Mouse
Reactivity: Vertebrates
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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