Focal adhesion kinase (FAK) is a non-receptor protein-tyrosine kinase that localizes to the cytoplasm and is concentrated in focal adhesions, macromolecular assemblies that form a communicative link between the cell and the extracellular matrix. FAK signaling is stimulated by integrin-mediated responses, as well as growth factors, chemokines, and G-protein-linked receptors. FAK signaling influences cell motility, invasion, and survival. Alternate names for FAK include FADK1, pp125FAK, protein-tyrosine kinase 2, PTK2 protein tyrosine kinase 2, PTK2, and FAK1.
Anti-PTK2 protein tyrosine kinase 2 isoform b variant