Anti-Estrogen Receptor alpha, clone MSVA-564R

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. Estrogen receptor alpha (ESR1) is a ligand-activated nuclear hormone receptor that regulates gene transcription in response to estrogen signaling and plays a central role in the growth and differentiation of hormone-responsive tissues. Estrogen receptor alpha Antibody for IHC is widely used to detect nuclear ESR1 expression in formalin-fixed, paraffin-embedded samples, where it serves as a key marker of hormone receptor status in tissue-based analysis. ESR1, also referred to as Estrogen receptor 1 in the literature, functions as a signal-dependent transcriptional regulator that converts estrogen binding into coordinated gene expression programs governing cellular proliferation, differentiation, and tissue organization.In immunohistochemistry, Estrogen receptor alpha is characteristically observed as strong nuclear staining in epithelial cells of hormone-responsive tissues, including breast, uterus, and ovary, while most stromal and non-hormone-responsive cell types show minimal staining. This nuclear localization reflects its role as a transcription factor and provides clear contrast in tissue sections, making ESR1 a highly interpretable marker in histological analysis. Estrogen receptor alpha Antibody detection therefore supports evaluation of receptor distribution, cellular localization, and tissue-specific expression patterns.Tissue microarray (TMA) analysis enables simultaneous assessment of Estrogen receptor alpha expression across a wide range of normal and cancer tissues, revealing consistent nuclear staining in hormone receptor-positive tumors, particularly in breast carcinoma. Variability in staining intensity and distribution across tumor samples reflects differences in receptor expression levels and cellular heterogeneity within the tumor microenvironment. Estrogen receptor alpha Antibody is therefore valuable for comparative tissue profiling and large-scale analysis of hormone receptor expression patterns. This antibody is part of a broader collection of IHC antibodies validated by tissue microarray analysis, supporting consistent staining across normal and cancer tissues.Alterations in ESR1 expression and signaling are closely associated with changes in tissue differentiation and hormone responsiveness. In tumor tissues, nuclear ESR1 staining highlights populations of hormone-responsive epithelial cells and supports studies examining tumor classification and cellular phenotype. Evaluation of Estrogen receptor alpha at the tissue level provides insight into how estrogen signaling contributes to changes in cellular organization and disease-associated expression patterns.Clone MSVA-564R is designed to recognize Estrogen receptor alpha in research applications. Estrogen receptor alpha Antibody reagents are suitable for detecting nuclear ESR1 expression in tissue sections and supporting studies focused on tissue distribution, tumor characterization, and hormone-responsive signaling in histological models.For comprehensive detection of Estrogen receptor alpha across hormone signaling and breast cancer studies, see our Estrogen Receptor alpha antibody (clone ESR1/3557).