448 products were found matching "K08550"!

Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...

Androgen receptor ligand 3 is an estrogen receptor (ER) ligand (KD = 0.39 µM in a radioligand binding assay) and an oxime derivative of estrone (Cay-10006485). Androgen receptor ligand 3 has been used in the synthesis of a specific and nongenetic IAP-dependent protein eraser (SNIPER) that decreases ERalpha levels in...

0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide. ESR1 antibody Recombinant Mouse MAb rESR1/9525 targets Estrogen receptor 1, a nuclear hormone receptor encoded by the ESR1 gene that is also widely referred to as estrogen receptor alpha and ER alpha in the literature. Estrogen receptor 1 functions as a...

1 mg/ml in 1X PBS, BSA free, sodium azide free. ESR1 antibody Recombinant Mouse MAb rESR1/9525 targets Estrogen receptor 1, a nuclear hormone receptor encoded by the ESR1 gene that is also widely referred to as estrogen receptor alpha and ER alpha in the literature. Estrogen receptor 1 functions as a...

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. Estrogen receptor alpha (ESR1) is a ligand-activated nuclear hormone receptor that regulates gene transcription in response to estrogen signaling and plays a central role in the growth and differentiation of hormone-responsive tissues. Estrogen receptor alpha...

A selective estrogen receptor degrader, induces degradation of wild-type ERalpha and ERalphaY537S at 100 nM, reduces growth of ER+ T47D and MCF-7 cells (IC50s = 0.34 and 5.2 nM, respectively) but not MDA-MB-231 cells, reduces growth of ERalphaY537S -expressing T47D and MCF-7 cells (IC50s = 113 and 512 nM,...

A selective estrogen receptor modulator, an ERalpha antagonist (Ki = 2.7 nM) and is selective for ERalpha over ERbeta (Ki = 1,800 nM), induces apoptosis in RL-95 cells at 1 nM, increases uterine weight in ovariectomized mice at 25, 50, and 100 µg/animal. SMILES:...

Description: Lasofoxifene (CP-336156) is a selective, orally active estrogen receptor modulator (SERM) that inhibits the growth and metastasis of primary tumours and is also anti-osteoporotic. Target: Others. Smiles: OC=1C=C2C([C@H]([C@H](CC2)C3=CC=CC=C3)C4=CC=C(OCCN5CCCC5)C=C4)=CC1

(E)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen (Cay-13258, Cay-11629) and (Z)-4-hydroxy tamoxifen (Cay-14854). It is formed from tamoxifen via transisomerization of the (Z)-4-hydroxy tamoxifen intermediate by the cytochrome P450 isoforms CYP1A1, CYP1B1, CYP2B6, CYP2D6, CYP3A4, and CYP3A5. (E)-4-hydroxy...

Estradiol undecylate is a synthetic estrogen. It induces vaginal keratinization in ovariectomized rats when administered subcutaneously at a dose of 100 µg/animal. Estradiol undecylate (40 µg/animal) induces vaginal estrus for 80 days in ovariectomized rats. Formal Name: estra-1,3,5(10)-triene-3,17-diol,...

Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...

ESR1(estrogen receptor 1) Homo sapiens This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with...