436 products were found matching "K08550"!

Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...

ZK 164015 is an estrogen receptor antagonist (IC50 = 25 nM in a reporter assay). It inhibits the proliferation of MCF-7 breast cancer cells stimulated with E2 (17beta-estradiol, IC50 = 51 nM) and unstimulated MCF-7 cells (IC50 = 1.4 nM). ZK 164015 does not increase uterine weight in mice. It also inhibits the growth...

Androgen receptor ligand 3 is an estrogen receptor (ER) ligand (KD = 0.39 µM in a radioligand binding assay) and an oxime derivative of estrone (Cay-10006485). Androgen receptor ligand 3 has been used in the synthesis of a specific and nongenetic IAP-dependent protein eraser (SNIPER) that decreases ERalpha levels in...

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. Estrogen receptor alpha (ESR1) is a ligand-activated nuclear hormone receptor that regulates gene transcription in response to estrogen signaling and plays a central role in the growth and differentiation of hormone-responsive tissues. Estrogen receptor alpha...

0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide. ESR1 antibody Recombinant Mouse MAb rESR1/9525 targets Estrogen receptor 1, a nuclear hormone receptor encoded by the ESR1 gene that is also widely referred to as estrogen receptor alpha and ER alpha in the literature. Estrogen receptor 1 functions as a...

1 mg/ml in 1X PBS, BSA free, sodium azide free. ESR1 antibody Recombinant Mouse MAb rESR1/9525 targets Estrogen receptor 1, a nuclear hormone receptor encoded by the ESR1 gene that is also widely referred to as estrogen receptor alpha and ER alpha in the literature. Estrogen receptor 1 functions as a...

A selective estrogen receptor degrader, induces degradation of wild-type ERalpha and ERalphaY537S at 100 nM, reduces growth of ER+ T47D and MCF-7 cells (IC50s = 0.34 and 5.2 nM, respectively) but not MDA-MB-231 cells, reduces growth of ERalphaY537S -expressing T47D and MCF-7 cells (IC50s = 113 and 512 nM,...

A selective estrogen receptor modulator, an ERalpha antagonist (Ki = 2.7 nM) and is selective for ERalpha over ERbeta (Ki = 1,800 nM), induces apoptosis in RL-95 cells at 1 nM, increases uterine weight in ovariectomized mice at 25, 50, and 100 µg/animal. SMILES:...

Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...

Description: Lasofoxifene (CP-336156) is a selective, orally active estrogen receptor modulator (SERM) that inhibits the growth and metastasis of primary tumours and is also anti-osteoporotic. Target: Others. Smiles: OC=1C=C2C([C@H]([C@H](CC2)C3=CC=CC=C3)C4=CC=C(OCCN5CCCC5)C=C4)=CC1

Synthetic. Chemical. CAS: 54965-24-1. Formula: C26H29NO . C6H8O7. MW: 563.64. Synthetic. Selective estrogen receptor modulator (SERM) used as adjuvant therapy for estrogen-dependent breast cancer. Antagonist of ER action in breast tissue and breast cancer cells and ER agonist in bone, uterus, and the...

ESR1(estrogen receptor 1) Homo sapiens This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with...