359 products were found matching "K08550"!

Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...

10-Chloroestra-1,4-diene-3,17-dione is a sterone agonist of estrogen receptor alpha (ERalpha). It increases reporter gene expression in S. cerevisiae (EC50 = 0.36 nM for the human receptor). It also is an aromatase inhibitor (IC50 = 2.4 µM).Formal Name: 10-chloro-estra-1,4-diene-3,17-dione. CAS Number: 91413-55-7....

Estrogen receptors are a group of proteins found inside cells. Estrogen receptor alpha (ERalpha), a member of the steroid receptor superfamily, contains highly conserved DNA binding and ligand binding domains. Protein function: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the...

Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE)...

Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...

Elacestrant is a selective estrogen receptor degrader (SERD). It selectively binds to estrogen receptor alpha (ERalpha) over ERbeta (IC50s = 48 and 870 nM, respectively) and reduces ERalpha levels in MCF-7 cells (EC50 = 0.6 nM). Elacestrant reduces MCF-7 proliferation induced by 17beta-estradiol (E2, Cay-10006315)...

CMP8 is a mutant estrogen receptor alpha (ERalpha) antagonist and ligand used for bump and hole, a technique to study single protein isoforms when familial homology would interfere with other isoform-selective approaches. It is selective for an ERalpha triple mutant containing a lysine-to-methionine substitution at...

Fulvestrant is a selective estrogen receptor degrader (SERD) that downregulates and degrades estrogen receptor alpha (ERalpha). It binds to rat uterine ER with an IC50 value of 44.8 nM and prevents uterine weight increases induced by estradiol in immature rats (ED50> = 0.06 mg/kg per day) but has no effect on...

Synthetic. Chemical. CAS: 54965-24-1. Formula: C26H29NO . C6H8O7. MW: 563.64. Synthetic. Selective estrogen receptor modulator (SERM) used as adjuvant therapy for estrogen-dependent breast cancer. Antagonist of ER action in breast tissue and breast cancer cells and ER agonist in bone, uterus, and the...

A synthetic estrogen receptor antagonist. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines.

(E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen (Cay-13258). It is formed from tamoxifen by the cytochrome P450 (CYP) isoform CYP2D6. (E/Z)-4-hydroxy Tamoxifen is cytotoxic to MCF-7 and MDA-MB-231 breast cancer cells (IC50s = 27 and 18 µM, respectively). It also stimulates LC3 lipidation and the...

Diethylstilbestrol (DES) is a synthetic estrogen receptor agonist that was prescribed to pregnant women in the late 1930s. It was banned in 1971 because of possible links to increased risk of breast cancer in mothers along with congenital abnormalities and increased risk of cancer in offspring. DES is structurally...