432 products were found matching "K08550"!

Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...

ESR1(estrogen receptor 1) Homo sapiens This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with...

(E)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen (Cay-13258, Cay-11629) and (Z)-4-hydroxy tamoxifen (Cay-14854). It is formed from tamoxifen via transisomerization of the (Z)-4-hydroxy tamoxifen intermediate by the cytochrome P450 isoforms CYP1A1, CYP1B1, CYP2B6, CYP2D6, CYP3A4, and CYP3A5. (E)-4-hydroxy...

Estradiol undecylate is a synthetic estrogen. It induces vaginal keratinization in ovariectomized rats when administered subcutaneously at a dose of 100 µg/animal. Estradiol undecylate (40 µg/animal) induces vaginal estrus for 80 days in ovariectomized rats. Formal Name: estra-1,3,5(10)-triene-3,17-diol,...

Estrogen receptor antagonist 2 is a degrader of estrogen receptor alpha (ERalpha). It induces degradation of ERalpha in MCF-7 breast cancer cells (IC50 = 0.16 nM). Estrogen receptor antagonist 2 inhibits estradiol-induced growth in MCF-7 cells (IC50 = 5.01 nM). In vivo, estrogen receptor antagonist 2 (0.5-50 mg/kg...

Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...

Synthetic. Chemical. CAS: 54965-24-1. Formula: C26H29NO . C6H8O7. MW: 563.64. Synthetic. Selective estrogen receptor modulator (SERM) used as adjuvant therapy for estrogen-dependent breast cancer. Antagonist of ER action in breast tissue and breast cancer cells and ER agonist in bone, uterus, and the...

Fulvestrant is a selective estrogen receptor degrader (SERD) that downregulates and degrades estrogen receptor alpha (ERalpha). It binds to rat uterine ER with an IC50 value of 44.8 nM and prevents uterine weight increases induced by estradiol in immature rats (ED50> = 0.06 mg/kg per day) but has no effect on...

An ERalpha degrader (IC50 = 4.1 nM), inhibits estradiol-induced ERalpha transcriptional activity in a reporter assay using T47D cells at 1 or 10 nM, decreases the proliferation of MCF-7 and T47D cells and tamoxifen-resistant MCF-7 and T47D cells (IC50s = 0.0032, 0.0062, 0.069, and 0.037 nM, respectively)....

A synthetic estrogen receptor antagonist. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines.

Synthetic. Chemical. CAS: 10540-29-1. Formula: C26H29NO. MW: 371.51. Synthetic. Selective estrogen receptor modulator (SERM) used as adjuvant therapy for estrogen-dependent breast cancer. Antagonist of ER action in breast tissue and breast cancer cells and ER agonist in bone, uterus, and the cardiovasculature...

(E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen (Cay-13258). It is formed from tamoxifen by the cytochrome P450 (CYP) isoform CYP2D6. (E/Z)-4-hydroxy Tamoxifen is cytotoxic to MCF-7 and MDA-MB-231 breast cancer cells (IC50s = 27 and 18 µM, respectively). It also stimulates LC3 lipidation and the...