367 products were found matching "K08550"!
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Tamoxifen
Item number: Cay13258-1
Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...
| Keywords: | 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine |
| Application: | Estrogen receptor modulator |
| CAS | 10540-29-1 |
| MW: | 371.5 D |
From 78.00€
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LSZ-102
Item number: Cay41834-1
LSZ-102 is an estrogen receptor alpha (ERalpha) degrader (IC50 = 0.2 nM). It reduces 17beta-estradiol-induced transcription in a reporter assay using MCF-7 breast cancer cells expressing ERalpha (IC50 = 6 nM). LSZ-102 decreases the proliferation of MCF-7 cells (IC50 = 1.7 nM). In vivo, LSZ-102 (20 mg/kg per day)...
| Keywords: | 3-[4-[[2E-[2-(1,1-difluoroethyl)-4-fluorophenyl]-6-hydroxybenzo[b]thien-3-yl]oxy]phenyl]-2-propenoic acid |
| Application: | ERalpha degrader |
| CAS | 2135600-76-7 |
| MW: | 470.5 D |
From 62.00€
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Raloxifene
Item number: Cay41845-1
Raloxifene (Cay-41845) is an analytical reference standard categorized as a selective estrogen receptor modulator (SERM). It has been detected as an adverse analytical finding (AAF) during anti-doping testing. This product is intended for analytical forensic applications. This product is also available as a general...
| Keywords: | Keoxifene, LY156758, NSC 747974,... |
| Application: | Analytical reference standard, selective estrogen receptor modulator (SERM) |
| CAS | 84449-90-1 |
| MW: | 473.6 D |
From 150.00€
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Tamoxifen (citrate)
Item number: Cay11629-10
Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...
| Keywords: | ICI 46474, Istubal, Kessar, Noltam, Nolvadex, TMX, Valodex, Zemide,... |
| Application: | Estrogen receptor (ER) modulator, Apoptosis inducer |
| CAS | 54965-24-1 |
| MW: | 563.6 D |
From 60.00€
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Palazestrant
Item number: TGM-T72945-10mg
Description: Palazestrant (OP-1250) is an orally available and highly potent estrogen receptor antagonist and selective ER degrader with antitumor activity.Palazestrant inhibits 17b-estradiol (E2), inhibits MCF7 and CAMA-1 cell proliferation, and can be used in breast cancer research. Target: Estrogen/progestogen...
| Keywords: | OP1250, OP 1250, OP-1250 |
| Application: | Targets estrogen receptor alpha (ESR1, NR3A1) |
| CAS | 2092925-89-6 |
| MW: | 449.6 D |
From 292.00€
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Glycitein
Item number: TGM-T6S0325-1mL
Description: 1. Gycitein has weak estrogenic activity. 2. Glycitein (Glycetein) inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression. Target: Apoptosis, Others. Smiles: COc1cc2c(cc1O)occ(-c1ccc(O)cc1)c2=O. References: Pan W , Ikeda K , Takebe M , et al. Genistein, daidzein and...
| Keywords: | Glycetein |
| Application: | Metabolic studies |
| CAS | 40957-83-3 |
| MW: | 284.26 D |
From 49.00€
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10-Chloroestra-1,4-diene-3,17-dione
Item number: TGM-T83907-10mg
Description: 10-Chloroestra-1,4-diene-3,17-dione acts as an estrogen receptor alpha (ERalpha) agonist, enhancing reporter gene expression in S. cerevisiae with an EC50 of 0.36 nM for the human receptor. Additionally, it functions as an aromatase inhibitor, exhibiting an IC50 of 2.4 µM. Target: Others. Smiles:...
| Keywords: | 10-chloro-1,4-Estradiene |
| Application: | Sterone ERalpha agonist |
| CAS | 91413-55-7 |
| MW: | 304.8 D |
From 75.00€
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BE-26263
Item number: TGM-T85037-10mg
Description: BE-26263, an antiosteoporotic agent isolated from Scedosporium apiospermum, exhibits an estrogenic effect [1]. Target: Others. Smiles: OC1=C2C(=CC(O)=C1)CC(C)OC(=O)CC(C)OC(=O)CC(C)OC(=O)C=3C(CC(C)OC(=O)CC(C)OC2=O)=CC(O)=CC3O
| Application: | Fungal metabolite |
| CAS | 147716-81-2 |
| MW: | 646.64 D |
Please request pricing for this article.
ER alpha Protein, Human, Recombinant (His)
Item number: TGM-TMPJ-00762-10ug
Description: Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a...
| Keywords: | ER, Nuclear Receptor Subfamily 3 Group A Member 1, ESR, Estradiol Receptor, ER alpha, Estrogen Receptor, estrogen receptor... |
| MW: | 14 kD |
From 181.00€
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Hexestrol
Item number: TGM-T6533-100mg
Description: Hexestrol (Hexanoestrol) binds to ERalpha and ERbeta with EC50 of 0.07 nM and 0.175 nM, respectively. Target: Estrogen/progestogen Receptor, Estrogen Receptor/ERR. Smiles: [C@H]([C@H](CC)C1=CC=C(O)C=C1)(CC)C2=CC=C(O)C=C2. References: Waibel M, et al. Eur J Med Chem, 2009, 44(9), 3412-3424.
| Keywords: | Bibenzyl, meso-Hexestrol, Hexestrofen, Hexanoestrol |
| Application: | Synthetic non-steroidal estrogen receptor ligand |
| CAS | 84-16-2 |
| MW: | 270.37 D |
From 40.00€
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Tamoxifen citrate salt
Item number: CDX-T0201-G001
Synthetic. Chemical. CAS: 54965-24-1. Formula: C26H29NO . C6H8O7. MW: 563.64. Synthetic. Selective estrogen receptor modulator (SERM) used as adjuvant therapy for estrogen-dependent breast cancer. Antagonist of ER action in breast tissue and breast cancer cells and ER agonist in bone, uterus, and the...
| Keywords: | (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene, ICI 46474, Istubal, Kessar, Noltam, Nolvadex, TMX, Valodex, Zemide |
| Application: | Selective estrogen receptor modulator |
| CAS | 54965-24-1 |
| MW: | 563,64 D |
From 85.00€
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Elacestrant
Item number: TGM-T13674-1mg
Description: Elacestrant (RAD1901) with IC50s of 48 and 870 nM for ERalpha and ERbeta, respectively.Elacestrant is an orally available selective estrogen receptor degrader . Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor. Smiles: CCNCCc1ccc(CN(CC)c2cc(OC)ccc2[C@@H]2CCc3cc(O)ccc3C2)cc1. References:...
| Keywords: | RAD1901 |
| Application: | Targets estrogen receptor alpha (ESR1, NR3A1) |
| CAS | 722533-56-4 |
| MW: | 458.63 D |
From 145.00€
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