Anti-ESR2 / Estrogen Receptor beta, clone ESR2/9710

1 mg/ml in 1X PBS, BSA free, sodium azide free. ER beta antibody targets Estrogen receptor beta, a nuclear hormone receptor encoded by the ESR2 gene and also referred to as Estrogen receptor 2 and ER beta in the literature. Estrogen receptor beta belongs to the steroid hormone receptor superfamily and functions as a ligand-activated transcriptional regulator that mediates cellular responses to estrogen signaling. In contrast to Estrogen receptor alpha, ER beta often exerts modulatory and context-dependent effects on gene expression, contributing to balanced estrogen-responsive transcriptional programs.Estrogen receptor beta is predominantly localized to the nucleus, where ER beta binds estrogen response elements and interacts with transcriptional co-regulators to influence transcriptional output. In addition to direct DNA binding, Estrogen receptor beta can modulate transcription indirectly through cooperation with other transcription factors, allowing fine-tuning of estrogen-dependent gene regulation. ER beta antibody detection is therefore useful for studying nuclear receptor signaling dynamics and transcriptional control mechanisms.Expression of Estrogen receptor beta is observed across a broad range of tissues, including ovary, breast, prostate, lung, colon, and immune-associated tissues. ER beta activity has been linked to regulation of cellular differentiation, growth restraint, immune modulation, and tissue homeostasis. In many biological contexts, Estrogen receptor beta signaling counterbalances Estrogen receptor alpha-driven transcription, highlighting its role in maintaining estrogen signaling equilibrium.Altered expression or regulatory activity of Estrogen receptor beta has been associated with disease-related changes in hormone responsiveness. Dysregulation of ER beta-mediated transcriptional programs can contribute to abnormal cellular behavior, including altered proliferation and differentiation. Studying Estrogen receptor 2 at the level of ER beta-specific regulation provides insight into estrogen signaling pathways that extend beyond classical Estrogen receptor alpha biology.Clone ESR2/9710 is designed to recognize Estrogen receptor beta in research applications. ER beta antibody reagents are suitable for detecting nuclear Estrogen receptor beta expression and supporting studies focused on estrogen signaling balance, transcriptional regulation, and hormone-responsive gene expression control.For comprehensive detection of Estrogen receptor beta across hormone signaling and tumor biology studies, see our Estrogen Receptor beta antibody (clone ERb455).