Anti-EPAS1 / HIF-2 alpha

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG43450.100	100 µl		-	-	6 - 14 business days*		616.00€

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Protein function: Transcription factor involved in the induction of oxygen regulated genes.... more

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Product information "Anti-EPAS1 / HIF-2 alpha"

Protein function: Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT, heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD. [The UniProt Consortium]

Keywords:	Anti-HLF, Anti-HLF, Anti-EPAS1, Anti-EPAS-1, Anti-EPAS-1, Anti-BHLHE73, Anti-bHLHe73, Anti-bHLHe73, Anti-HIF2-alpha, Anti-HIF2-alpha, Anti-HIF-2-alpha, Anti-HIF-2-alpha, Anti-HIF-1-alpha-like factor, Anti-Member of PAS protein 2, Anti-HIF-1-alpha-like fac
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG43450

Properties

Application:	FC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	KLH-conjugated synthetic peptide between aa. 124-150 of Human EPAS1 / HIF-2 alpha
MW:	96 kD
Format:	Purified