59 products were found matching "K09095"!

Protein function: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of...

HIF-2alpha translation inhibitor 76 is an inhibitor of hypoxia-inducible factor-2alpha (HIF-2alpha) translation. It inhibits constitutive gene expression in a hypoxia-response element (HRE) reporter assay using VHL-deficient 786-O renal cell carcinoma (RCC) cells (IC50 = 5 µM). HIF-2alpha translation inhibitor 76...

HIF-2alpha antagonist 2 is an inhibitor of hypoxia-inducible factor-2alpha (HIF-2alpha) PAS-B domain heterodimerization. It binds to the HIF-2alpha PAS-B domain (Kd = 81 nM) to inhibit heterodimerization with the aryl hydrocarbon receptor nuclear translocator (ARNT) PAS-B domain in cell-free assays when used at...

Belzutifan is an inhibitor of hypoxia-inducible factor-2alpha (HIF-2alpha). It inhibits HIF-2alpha heterodimerization with the aryl hydrocarbon receptor nuclear translocator (ARNT) PAS-B domain in a cell-free assay (Ki = 23 nM), activation of HIF-2alpha in a reporter assay using 786-O renal cell carcinoma cells...

Description: Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2alpha inhibitor (IC50: 9 nM). Belzutifan , as a second-generation HIF-2alpha inhibitor, increases potency and improves pharmacokinetic profile. Target: HIF....

Anti-HO-1 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with HO-1 from Human, Mouse, Bovine, Canine, Guinea pig, Hamster, Monkey, Pig, Rabbit, and Rat based on 100% homology with the immunizing sequence. Does not cross-react with HO-2. Cross-reactivity with...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. HIF-2 alpha is also designated EPAS1 whose gene is mapped to 2p21-p16. The predicted mouse protein is 88% identical to human. The human gene contains 15 exons and spans at least 120 kb. The positions of the introns within the genomic region encoding the...

ELISA Type: Sandwich. Sensitivity: 0.094ng/mL. Range: 0.156--10ng/mL. Protein function: Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT, heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters....

ELISA Type: Sandwich. Sensitivity: 0.188ng/mL . Range: 0.313--20ng/mL . Protein function: Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT, heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. HIF-2 alpha is also designated EPAS1 whose gene is mapped to 2p21-p16. The predicted mouse protein is 88% identical to human EPAS1. The human EPAS1 gene contains 15 exons and spans at least 120 kb. The positions of the introns within the genomic region encoding...

Protein function: Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT, heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems...