Anti-EP4 Receptor (C-Term) PE

Prostaglandin E2 (PGE2) binds to four receptor subtypes: EP1, EP2, EP3, and EP4, which are all membrane-bound G protein-coupled receptors (GPCRs). The EP4 receptor was originally classified as the EP2 receptor but was not activated by the EP2 agonist butaprost (Cay-13740, Cay-13741) and was later found to be a distinct receptor with sequence differences. It is expressed in many tissues, including the intestine, heart, kidney, lungs, and brain, and is also expressed in peripheral blood leukocytes and macrophages. The EP4 receptor is coupled to Galphas, and its activation increases intracellular cAMP levels, leading to tissue-specific effects. It induces smooth muscle relaxation, angiogenesis, T cell expansion, osteoblast differentiation, and bone resorption and inhibits TNF-alpha production in monocytes and macrophages, among other activities. PTGER4, the gene encoding the EP4 receptor, is overexpressed in a variety of cancers, and antagonism of the receptor in animal models inhibits tumor growth and angiogenesis. In contrast, EP4 receptor activation has anti-inflammatory and neuroprotective activities in vitro and in animal models. Cayman's EP4 Receptor (C-Term) Polyclonal PE Antibody can be used for flow cytometry (FC) and immunofluorescence (IF) applications.Synonyms: Prostaglandin E2 Receptor 4. Immunogen: Synthetic peptide from the C-terminal cytoplasmic region of human EP4 receptor. Formulation: (Request formulation change), 100 µl of peptide affinity-purified polyclonal antibody conjugated to PE. Storage Buffer: PBS, pH 7.2, containing 50% glycerol with 0.02% sodium azide. Host: Rabbit. Applications: FC and IF. Cross Reactivity: (-) EP1 receptor, (-) EP2 receptor, (-) EP3 receptor. UniProt Accession #: P35408. Origin: Animal/Rabbit.