65 products were found matching "K04261"!
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Grapiprant
Item number: LKT-G681019.100
Grapiprant is an orally bioavailable antagonist of the prostaglandin E receptor subtype 4 (EP4), with potential analgesic, immunomodulating and antineoplastic activities. Upon administration of grapiprant, this agent selectively binds to and inhibits the binding of prostaglandin E2 (PGE2) and prevents the activation...
| Keywords: | CJ-023423, RQ-00000007, AAT-007,... |
| Application: | EP4 receptor antagonist |
| CAS | 415903-37-6 |
| MW: | 491.61 D |
From 150.00€
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L-161,982
Item number: Cay10011565-1
Prostaglandin E2 (PGE2) exerts its effects through four separate G coupled-protein receptors (EP1-4). L-161,982 is a potent and selective EP4 receptor antagonist. It demonstrates selective binding to human EP4 receptors with a Ki value of 0.024 µM compared to other receptors of the prostanoid family, EP1, EP2, EP3,...
| Keywords: | N-[[4'-[[3-butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfony... |
| Application: | EP4 receptor antagonist |
| CAS | 147776-06-5 |
| MW: | 654.7 D |
From 52.00€
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ER819762
Item number: TGM-T27279-5mg
Description: ER819762, an antagonist of the prostaglandin E2 EP4 receptor, inhibits Th1 differentiation and Th17 expansion. Target: Others. Smiles: C(C)N1C2(C=3N(C1=O)CC=4C([C@@H](C)C3)=C(OC)C=C(OC)C4)CCN(CC5=CC(C)=CC(C)=C5)CC2. References: Jones VC, Birrell MA, Maher SA, Griffiths M, Grace M, O'Donnell VB, Clark...
| Keywords: | ER 819762, ER-819762 |
| Application: | EP4 antagonist |
| CAS | 1155773-15-1 |
| MW: | 489.65 D |
861.00€
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KMN-80
Item number: TGM-T37441-1mg
Description: The prostaglandin E receptor 4 (EP4) is one of four G protein-coupled receptors that mediate the actions of prostaglandin E2 . Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP, which plays important roles in bone formation and resorption, cancer, and atherosclerosis....
| Application: | Selective, potent EP4 agonist |
| CAS | 1628759-75-0 |
| MW: | 363.49 D |
From 266.00€
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ASP7657
Item number: TGM-T71269-10mg
Description: ASP7657 is a novel, potent, and selective prostaglandin EP4 receptor antagonist. Target: Others. Smiles: C(NC[C@@H]1CC[C@@H](C(O)=O)CC1)(=O)C2=C3C(=CC(C(F)(F)F)=C2)C=CN3CC4=NC5=C(C=C4)C=CC=C5
| Application: | Prostaglandin E2 receptor EP4 subtype antagonist |
| CAS | 1196045-28-9 |
| MW: | 509.52 D |
From 170.00€
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MF-766
Item number: TGM-T9622-100mg
Description: MF-766 is a highly potent, selective, and orally active EP4 antagonist with a Ki of 0.23 nM, acting as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay. It is useful for cancer and inflammation diseases research [1][2]. Target: Prostaglandin...
| Application: | EP4 receptor antagonist |
| CAS | 1050656-06-8 |
| MW: | 478.46 D |
From 74.00€
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BGC-20-1531 hydrochloride(1186532-61-5 free base)
Item number: TGM-T8993L-10mg
Description: BGC-20-1531 hydrochloride(1186532-61-5 free base) (GTPL3380 hydrochloride) is a EP4 antagonist for the treatment of acute migraine. Target: Prostaglandin Receptor. Smiles: CC1=CC=CC=C1S(=O)(=O)NC(=O)C2=CC(=C(O2)C)COC3=CC=C(C=C3)C4=NC=C(C=C4)OC.Cl. References: Czigler A , Toth L , Szarka N , et al....
| Keywords: | GTPL3380 hydrochloride, BGC-20-1531 hydrochloride, AP-1531 hydrochloride |
| Application: | EP4 antagonist |
| CAS | 1962928-26-2 |
| MW: | 529 D |
From 133.00€
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ONO-AE3-208 sodium
Item number: TGM-T84444-10mg
Description: ONO-AE3-208 is an EP4 receptor antagonist with a Ki of 1.3 nM, exhibiting less potent activity against EP3, FP, and TP receptors (Ki values of 30, 790, and 2,400 nM, respectively), while showing no effect on other prostanoid receptors. In wild type mice, treatment with ONO-AE3-208, in conjunction with...
| Application: | EP4 receptor antagonist |
| CAS | 2309931-05-1 |
| MW: | 426.42 D |
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Grapiprant
Item number: TGM-TQ0292-100mg
Description: Grapiprant (AAT-007) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 nM). Target: Prostaglandin Receptor. Smiles: CCc1nc2c(C)nc(C)cc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1. References: Vito VD, et al....
| Keywords: | AAT-007, CJ-023423, RQ-00000007 |
| Application: | Targets prostaglandin E receptor 4 (PTGER4) |
| CAS | 415903-37-6 |
| MW: | 491.61 D |
From 31.00€
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E7046
Item number: TGM-TQ0025-10mg
Description: E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities. Target: Prostaglandin Receptor. Smiles: C[C@H](NC(=O)c1c(nn(C)c1Oc1cccc(c1)C(F)(F)F)C(F)F)c1ccc(cc1)C(O)=O. References: Diana I. Albu, et al. EP4 Antagonism by E7046 diminishes...
| Application: | EP4 antagonist |
| CAS | 1369489-71-3 |
| MW: | 483.4 D |
From 48.00€
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CAY10598
Item number: Cay13281-500
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CAY10598 is a very potent agonist of EP4, binding with a Ki value of 1.2...
| Keywords: | 5-[(3S)-3-hydroxy-4-phenyl-1-buten-1-yl]1-[6-(2H-tetrazol-5R-yl)hexyl]-2-pyrrolidinone |
| Application: | EP4 agonist |
| CAS | 346673-06-1 |
| MW: | 383.5 D |
From 132.00€
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L-902,688
Item number: Cay10007712-1
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. L-902,688 is a highly potent agonist of the human PGE2 receptor, EP4. It...
| Keywords: | 5-[(1E,3R)-4,4-difluoro-3-hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5R-yl)hexyl]-2-pyrrolidinone |
| Application: | EP4 agonist |
| CAS | 634193-54-7 |
| MW: | 419.5 D |
From 153.00€
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