35 products were found matching "K04261"!

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L-902,688
L-902,688

Item number: Cay10007712-1

Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. L-902,688 is a highly potent agonist of the human PGE2 receptor, EP4. It...
Keywords: 5-[(1E,3R)-4,4-difluoro-3-hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5R-yl)hexyl]-2-pyrrolidinone
Application: EP4 agonist
CAS 634193-54-7
MW: 419.5 D
From 150.00€ *
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EP4 Antagonist 14
EP4 Antagonist 14

Item number: Cay38427-1

EP4 antagonist 14 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 with an IC50 value of 1.1 nM in a reporter assay using HEK293 cells expressing the human receptor. It inhibits PGE2-induced beta-arrestin recruitment in the same cells (IC50 = 0.9 nM). EP4 antagonist 14 (10 µM) decreases...
Keywords: PGE2 Receptor 4 Antagonist 14, Prostaglandin E2 Receptor 4 Antagonist 14,...
Application: EP4 receptor (prostaglandin E receptor 4) antagonist
MW: 453.4 D
From 90.00€ *
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AMX12006
AMX12006

Item number: Cay39027-10

AMX12006 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 (IC50 = 4.3 nM). It is selective for EP4 over EP1, EP2, and EP3 receptors (IC50s = >10 µM for all). AMX12006 is cytotoxic to MCF-7 and 4T1 breast and CT26 colon cancer cells (IC50s = 46.73, 79.47, and 41.39 µM, respectively). It reduces...
Keywords: 4-[(1S)-1-[[[1-methyl-3-[[3-(trifluoromethyl)phenyl]amino]-1H-indol-2-yl]carbonyl]amino]ethyl]-benzoic acid
Application: EP4 receptor (prostaglandin E receptor 4) antagonist
CAS 2639775-01-0
MW: 481.5 D
From 77.00€ *
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L-161,982
L-161,982

Item number: Cay10011565-1

Prostaglandin E2 (PGE2) exerts its effects through four separate G coupled-protein receptors (EP1-4). L-161,982 is a potent and selective EP4 receptor antagonist. It demonstrates selective binding to human EP4 receptors with a Ki value of 0.024 µM compared to other receptors of the prostanoid family, EP1, EP2, EP3,...
Keywords: N-[[4'-[[3-butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfony...
Application: EP4 receptor antagonist
CAS 147776-06-5
MW: 654.7 D
From 50.00€ *
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CAY10598
CAY10598

Item number: Cay13281-500

Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CAY10598 is a very potent agonist of EP4, binding with a Ki value of 1.2...
Keywords: 5-[(3S)-3-hydroxy-4-phenyl-1-buten-1-yl]1-[6-(2H-tetrazol-5R-yl)hexyl]-2-pyrrolidinone
Application: EP4 agonist
CAS 346673-06-1
MW: 383.5 D
From 129.00€ *
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ONO-AE3-208
ONO-AE3-208

Item number: Cay14522-5

ONO-AE3-208 is an antagonist of the EP4 receptor (Ki = 1.3 nM) which less potently affects EP3, FP, and TP receptors (Kis = 30, 790, and 2,400 nM, respectively) and is without effect on other prostanoid receptors. In wild type mice, it mimics deletion of EP4 by producing severe colitis, with epithelial loss, crypt...
Keywords: 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-benzenebutanoic acid
Application: EP4 receptor antagonist
CAS 402473-54-5
MW: 404.4 D
From 60.00€ *
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CJ-42794
CJ-42794

Item number: Cay10010428-10

Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CJ-42794 is a selective antagonist of EP4 (Ki = 3.16 nM) that less...
Keywords: RQ-00015986, 4-[(1S)-1-[[5-chloro-2-(4-fluorophenoxy)benzoyl]amino]ethyl]-benzoic acid
Application: EP4 receptor agonist
CAS 847728-01-2
MW: 413.8 D
From 72.00€ *
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ER-819762
ER-819762

Item number: Cay10531-1

ER-819762 is an antagonist of the prostaglandin E2 (PGE2, Cay-14010) receptor subtype EP4 (IC50 = 70 nM). It is selective for EP4 over EP1, EP2, and EP3 in a cAMP reporter assay at 10 µM. ER-819762 reduces differentiation of mouse helper T cells when used at concentrations ranging from 0.1 to 10 nM and decreases...
Keywords: (10S)-1'-[(3,5-dimethylphenyl)methyl]-2-ethyl-5,10-dihydro-7,9-dimethoxy-10-methyl-spiro[1H-imidazo[1,5-b][2]benzazepine-1...
Application: EP4 antagonist
CAS 1155773-15-1
MW: 489.7 D
From 104.00€ *
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CJ-023423
CJ-023423

Item number: Cay10010355-1

Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CJ-023423 is a potent and selective antagonist of the EP4 receptor (Ki =...
Keywords: Grapiprant, RQ-00000007,...
Application: EP4R antagonist
CAS 415903-37-6
MW: 491.6 D
From 43.00€ *
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CAY10684
CAY10684

Item number: Cay15966-1

Prostaglandin E2 (PGE2, Cay-14010) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a G protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CAY10684 is a lactam that acts as a potent EP4 agonist,...
Keywords: (2R)-2-[(1E)-3-(4'-chloro-2'-methyl[1,1'-biphenyl]-3-yl)-3-hydroxy-1-propen-1-yl]-5-oxo-1-pyrrolidineheptanoic acid
Application: EP4 agonist
CAS 493035-81-7
MW: 470 D
From 127.00€ *
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tetranor-Misoprostol
tetranor-Misoprostol

Item number: Cay22693-25

tetranor-Misoprostol is a metabolite of misoprostol (Cay-13820). It is formed when misoprostol undergoes rapid de-esterification to form misoprostol (free acid) (Cay-13821), which is further metabolized to form the more polar tetranor-misoprostol in rats, dogs, and monkeys.Formal Name:...
Keywords: 3-((1R,2R,3R)-3-hydroxy-2-((E)-4-hydroxy-4-methyloct-1-en-1-yl)-5-oxocyclopentyl)propanoic acid
Application: Misoprostol metabolite
MW: 312.4 D
From 179.00€ *
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E7046
E7046

Item number: Cay19673-10

E7046 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 (IC50 = 13.5 nM). It inhibits PGE2-induced activation of pro-tumor type 2 macrophages and prevents PGE2-induced suppression of T cell proliferation in isolated human peripheral blood monocytes (PBMCs) when used at concentrations ranging from...
Keywords: 4-[(1S)-1-[[[3-(difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]-1H-pyrazol-4-yl]carbonyl]amino]ethyl]-benzoic acid
Application: EP4 antagonist
CAS 1369489-71-3
MW: 483.4 D
From 60.00€ *
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