- Search results for K04261
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35 products were found matching "K04261"!
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Item number: Cay10007712-1
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. L-902,688 is a highly potent agonist of the human PGE2 receptor, EP4. It...
Keywords: | 5-[(1E,3R)-4,4-difluoro-3-hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5R-yl)hexyl]-2-pyrrolidinone |
Application: | EP4 agonist |
CAS | 634193-54-7 |
MW: | 419.5 D |
From 150.00€
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Item number: Cay38427-1
EP4 antagonist 14 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 with an IC50 value of 1.1 nM in a reporter assay using HEK293 cells expressing the human receptor. It inhibits PGE2-induced beta-arrestin recruitment in the same cells (IC50 = 0.9 nM). EP4 antagonist 14 (10 µM) decreases...
Keywords: | PGE2 Receptor 4 Antagonist 14, Prostaglandin E2 Receptor 4 Antagonist 14,... |
Application: | EP4 receptor (prostaglandin E receptor 4) antagonist |
MW: | 453.4 D |
From 90.00€
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Item number: Cay39027-10
AMX12006 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 (IC50 = 4.3 nM). It is selective for EP4 over EP1, EP2, and EP3 receptors (IC50s = >10 µM for all). AMX12006 is cytotoxic to MCF-7 and 4T1 breast and CT26 colon cancer cells (IC50s = 46.73, 79.47, and 41.39 µM, respectively). It reduces...
Keywords: | 4-[(1S)-1-[[[1-methyl-3-[[3-(trifluoromethyl)phenyl]amino]-1H-indol-2-yl]carbonyl]amino]ethyl]-benzoic acid |
Application: | EP4 receptor (prostaglandin E receptor 4) antagonist |
CAS | 2639775-01-0 |
MW: | 481.5 D |
From 77.00€
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Item number: Cay10011565-1
Prostaglandin E2 (PGE2) exerts its effects through four separate G coupled-protein receptors (EP1-4). L-161,982 is a potent and selective EP4 receptor antagonist. It demonstrates selective binding to human EP4 receptors with a Ki value of 0.024 µM compared to other receptors of the prostanoid family, EP1, EP2, EP3,...
Keywords: | N-[[4'-[[3-butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfony... |
Application: | EP4 receptor antagonist |
CAS | 147776-06-5 |
MW: | 654.7 D |
From 50.00€
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Item number: Cay13281-500
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CAY10598 is a very potent agonist of EP4, binding with a Ki value of 1.2...
Keywords: | 5-[(3S)-3-hydroxy-4-phenyl-1-buten-1-yl]1-[6-(2H-tetrazol-5R-yl)hexyl]-2-pyrrolidinone |
Application: | EP4 agonist |
CAS | 346673-06-1 |
MW: | 383.5 D |
From 129.00€
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Item number: Cay14522-5
ONO-AE3-208 is an antagonist of the EP4 receptor (Ki = 1.3 nM) which less potently affects EP3, FP, and TP receptors (Kis = 30, 790, and 2,400 nM, respectively) and is without effect on other prostanoid receptors. In wild type mice, it mimics deletion of EP4 by producing severe colitis, with epithelial loss, crypt...
Keywords: | 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-benzenebutanoic acid |
Application: | EP4 receptor antagonist |
CAS | 402473-54-5 |
MW: | 404.4 D |
From 60.00€
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Item number: Cay10010428-10
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CJ-42794 is a selective antagonist of EP4 (Ki = 3.16 nM) that less...
Keywords: | RQ-00015986, 4-[(1S)-1-[[5-chloro-2-(4-fluorophenoxy)benzoyl]amino]ethyl]-benzoic acid |
Application: | EP4 receptor agonist |
CAS | 847728-01-2 |
MW: | 413.8 D |
From 72.00€
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Item number: Cay10531-1
ER-819762 is an antagonist of the prostaglandin E2 (PGE2, Cay-14010) receptor subtype EP4 (IC50 = 70 nM). It is selective for EP4 over EP1, EP2, and EP3 in a cAMP reporter assay at 10 µM. ER-819762 reduces differentiation of mouse helper T cells when used at concentrations ranging from 0.1 to 10 nM and decreases...
Keywords: | (10S)-1'-[(3,5-dimethylphenyl)methyl]-2-ethyl-5,10-dihydro-7,9-dimethoxy-10-methyl-spiro[1H-imidazo[1,5-b][2]benzazepine-1... |
Application: | EP4 antagonist |
CAS | 1155773-15-1 |
MW: | 489.7 D |
From 104.00€
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Item number: Cay10010355-1
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CJ-023423 is a potent and selective antagonist of the EP4 receptor (Ki =...
Keywords: | Grapiprant, RQ-00000007,... |
Application: | EP4R antagonist |
CAS | 415903-37-6 |
MW: | 491.6 D |
From 43.00€
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Item number: Cay15966-1
Prostaglandin E2 (PGE2, Cay-14010) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a G protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CAY10684 is a lactam that acts as a potent EP4 agonist,...
Keywords: | (2R)-2-[(1E)-3-(4'-chloro-2'-methyl[1,1'-biphenyl]-3-yl)-3-hydroxy-1-propen-1-yl]-5-oxo-1-pyrrolidineheptanoic acid |
Application: | EP4 agonist |
CAS | 493035-81-7 |
MW: | 470 D |
From 127.00€
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Item number: Cay22693-25
tetranor-Misoprostol is a metabolite of misoprostol (Cay-13820). It is formed when misoprostol undergoes rapid de-esterification to form misoprostol (free acid) (Cay-13821), which is further metabolized to form the more polar tetranor-misoprostol in rats, dogs, and monkeys.Formal Name:...
Keywords: | 3-((1R,2R,3R)-3-hydroxy-2-((E)-4-hydroxy-4-methyloct-1-en-1-yl)-5-oxocyclopentyl)propanoic acid |
Application: | Misoprostol metabolite |
MW: | 312.4 D |
From 179.00€
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Item number: Cay19673-10
E7046 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 (IC50 = 13.5 nM). It inhibits PGE2-induced activation of pro-tumor type 2 macrophages and prevents PGE2-induced suppression of T cell proliferation in isolated human peripheral blood monocytes (PBMCs) when used at concentrations ranging from...
Keywords: | 4-[(1S)-1-[[[3-(difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]-1H-pyrazol-4-yl]carbonyl]amino]ethyl]-benzoic acid |
Application: | EP4 antagonist |
CAS | 1369489-71-3 |
MW: | 483.4 D |
From 60.00€
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