Anti-EP4 Receptor (C-Term)

Prostaglandin E2 (PGE2) binds to four receptor subtypes: EP1, EP2, EP3, and EP4, which are all membrane-bound G protein-coupled receptors (GPCRs). The EP4 receptor was originally thought to be a subtype of the EP2 receptor but was later found to be a distinct receptor with sequence differences. It is expressed in many tissues, including the intestine, heart, kidney, lungs, and brain, and is also expressed in peripheral blood leukocytes and macrophages. The EP4 receptor is coupled to Galphas, and its activation increases intracellular cAMP levels leading to tissue-specific effects. It induces smooth muscle relaxation, angiogenesis, T cell expansion, osteoblast differentiation, and bone resorption and inhibits TNF-alpha production in monocytes and macrophages, among other activities. PTGER4, the gene encoding the EP4 receptor, is overexpressed in a variety of cancers, and antagonism of the receptor in animal models inhibits tumor growth and angiogenesis. In contrast, EP4 receptor activation has anti-inflammatory and neuroprotective activities in vitro and in animal models. Cayman's EP4 Receptor (C-Term) Polyclonal Antibody can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), and Western blot (WB) applications.Synonyms: PGE2 Receptor 4, Prostaglandin E2 Receptor 4. Immunogen: Synthetic peptide corresponding to the C-terminal region of the human EP4 receptor. Formulation: (Request formulation change), 500 µl of Peptide affinity-purified polyclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: ICC, IHC, and WB. Cross Reactivity: (+) EP4 receptor, (-) EP1, (-) EP2, (-) EP3. UniProt Accession #: P35408. Origin: Animal/Rabbit.