Anti-ENO2

Enolases are cytoplasmic glycolytic enzymes that may be involved in differentiation. Three enolase isoenzymes,alpha,beta and gamma ,phaare present in mammalian cells. The alpha form is expressed in most tissues,whereas the beta form is expressed in muscle tissue. The gamma enolase (ENO2),a homodimer,is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs inneural tissue during development. Protein function: Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival. [The UniProt Consortium]