Anti-EGF-Receptor (Epidermal Growth Factor Receptor), human

Item number Size Datasheet Manual SDS Delivery time Quantity Price
100-401-149 250 µl - -

3 - 9 business days*

Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating... more
Product information "Anti-EGF-Receptor (Epidermal Growth Factor Receptor), human"
Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [The UniProt Consortium]
Keywords: Anti-EGFR, Anti-ERBB, EC=, Anti-Proto-oncogene c-ErbB-1, Anti-Epidermal growth factor receptor, Anti-Receptor tyrosine-protein kinase erbB-1
Supplier: Rockland Immunochemicals
Supplier-Nr: 100-401-149


Application: ELISA, IHC, IP, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: synthetic peptide corresponding to amino acids 1168-1181 of human EGFR
Format: Serum

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow. more
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-EGF-Receptor (Epidermal Growth Factor Receptor), human"
Write a review
or to review a product.