Anti-EGF-Receptor (Epidermal Growth Factor Receptor), human

Item number Size Datasheet Manual SDS Delivery time Quantity Price
100-401-149 250 µl - -

3 - 9 business days*

506.00€
 
Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating... more
Product information "Anti-EGF-Receptor (Epidermal Growth Factor Receptor), human"
Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [The UniProt Consortium]
Keywords: Anti-EGFR, Anti-ERBB, EC=2.7.10.1, Anti-Proto-oncogene c-ErbB-1, Anti-Epidermal growth factor receptor, Anti-Receptor tyrosine-protein kinase erbB-1
Supplier: Rockland Immunochemicals
Supplier-Nr: 100-401-149

Properties

Application: ELISA, IHC, IP, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: synthetic peptide corresponding to amino acids 1168-1181 of human EGFR
Format: Serum

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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