Anti-EED

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
600-401-AZ1	100 µg		-	-	6 - 10 business days*		834.00€

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Anti-EED Antibody was affinity purified from monospecific antiserum by immunoaffinity... more

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Product information "Anti-EED"

Anti-EED Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Four alternatively spliced transcript variants have been observed. Protein function: Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. [The UniProt Consortium]

Keywords:	Anti-EED, Anti-hEED, Anti-WAIT-1, Anti-Polycomb protein EED, Anti-WD protein associating with integrin cytoplasmic tails 1
Supplier:	Rockland Immunochemicals
Supplier-Nr:	600-401-AZ1

Properties

Application:	ELISA, IFM, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	18 amino acid synthetic peptide near the N-terminus of human EED.
Format:	Purified