Item number Size Datasheet Manual SDS Delivery time Quantity Price
A304-105A-T 20 µl (2 blots) -

3 - 9 business days*

A304-105A-M 100 µl (10 blots) -

3 - 9 business days*

A304-105A 100 µl (100 µg) -

3 - 9 business days*

Protein function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to... more
Product information "Anti-E2-EPF"
Protein function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle- regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151). Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro, it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PubMed:16819549). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination (PubMed:20061386, PubMed:20622874). [The UniProt Consortium]
Keywords: Anti-UBE2S, Anti-E2EPF, Anti-E2-EPF, Anti-Ubiquitin-protein ligase S, Anti-Ubiquitin carrier protein S, Anti-Ubiquitin-conjugating enzyme E2 S, Anti-E2 ubiquitin-conjugating enzyme S, Anti-Ubiquitin-conjugating enzyme E2-EPF5
Supplier: Bethyl Laboratories
Supplier-Nr: A304-105A


Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Zebrafish, X. Laevis, X. Tropicalis, Bovine)
Immunogen: synthetic peptide. The epitope recognized by A304-105A-T maps to a region between residue 172 to 222 of human Ubiquitin-Conjugating Enzyme E2S using the numbering given in entry NP_055316.2 (GeneID 27338).
Format: Antigen Affinity Purified

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