Anti-E-Cadherin / CDH1, clone CDH1/1525

Anti-E-Cadherin / CDH1, clone CDH1/1525
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3190SAF-100UG 100 µg - -

3 - 10 business days

1 mg/ml in 1X PBS, BSA free, sodium azide free. Recognizes a protein of 80-120kDa, identified as... more
Product information "Anti-E-Cadherin / CDH1, clone CDH1/1525"
1 mg/ml in 1X PBS, BSA free, sodium azide free. Recognizes a protein of 80-120kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as beta-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma. Protein function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. [The UniProt Consortium]
Keywords: Anti-CDHE, Anti-CDH1, E-Cadherin Antibody / CDH1
Supplier: NSJ Bioreagents
Supplier-Nr: V3190SAF-100UG


Application: FC, IF, WB, IHC (paraffin)
Antibody Type: Monoclonal
Clone: CDH1/1525
Conjugate: No
Host: Mouse
Reactivity: Human. Not Suitable For Mouse, Rat Sample Testing
Immunogen: A full length recombinant human protein was used as the immunogen for the E-Cadherin antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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