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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
D9370-02.100 | 100 µg | - | - |
3 - 19 business days* |
644.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein... more
Product information "Anti-DRAM, NT (Damage-Regulated Autophagy Modulator)"
Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy (1), a process that degrades cytosolic proteins and organelles (reviewed in 2). It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes together promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers (3) highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml. See D9370-02A for control peptide., Optimal dilutions to be determined by the researcher. Positive Control: K562 cell lysate, Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-DRAM, Anti-DRAM1, Anti-Damage-regulated autophagy modulator, Anti-DNA damage-regulated autophagy modulator protein 1 |
Supplier: | United States Biological |
Supplier-Nr: | D9370-02 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | 16 amino acid peptide from near the amino terminus of human DRAM (GenBank accession no. AAH18435) |
Format: | Affinity Purified |
Database Information
KEGG ID : | K21955 | Matching products |
UniProt ID : | Q8N682 | Matching products |
Gene ID | GeneID 55332 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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