Anti-Dnmt3b

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG54845.100	100 µl		-	-	6 - 14 business days*		624.00€

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Protein function: Required for genome-wide de novo methylation and is essential for the... more

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Product information "Anti-Dnmt3b"

Protein function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co- repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398). [The UniProt Consortium]

Keywords:	Anti-DNMT3B, Anti-Dnmt3b, Anti-M.HsaIIIB, EC=2.1.1.37, Anti-DNA MTase HsaIIIB, Anti-DNA methyltransferase HsaIIIB, Anti-DNA (cytosine-5)-methyltransferase 3B
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG54845

Properties

Application:	IHC (paraffin), WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse
Immunogen:	KLH-conjugated synthetic peptide corresponding to aa. 389-417 of Human Dnmt3b
Format:	Purified