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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
D3931-70U.100 | 100 µg | - | - |
3 - 19 business days* |
947.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
DNMT3A is a 130kD member of the C5-methlytransferase family of molecules. It is expressed both... more
Product information "Anti-Dnmt3a (DNA (cytosine-5)-methyltransferase 3A, Dnmt3a, DNA Methyltransferase HsaIIIA, DNA MTase"
DNMT3A is a 130kD member of the C5-methlytransferase family of molecules. It is expressed both during development and in virtually all adult tissues except for small intestine. DNMT3A is a nuclear protein that is found associated with heterochromatin. It possesses DNA methyltransferase activity, and acts in a complex with DNMT3L in embryonic stem cells, forming a (3A)2:(3L)2 heterotetramer. It also interacts with SETDB1 to form a transcriptional repressor. Human DNMT3A is 912aa in length. It contains one ProTrpTrpPro domain aa292-350 and one ADD-type zinc finger region aa494-586. There is one 100kD splice variant termed DNMT3a2 that contains an alternative start site at Met224, and preferentially interacts with euchromatin. Other potential splice variants show a 16aa substitution for aa151-912, and a 24aa substitution for aa1-213. Over aa353-486, human DNMT3A shares 96% aa identity with mouse DNMT3A. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.1ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-DNMT3A, Anti-Dnmt3a, Anti-M.HsaIIIA, EC=2.1.1.37, Anti-DNA MTase HsaIIIA, Anti-DNA methyltransferase HsaIIIA, Anti-DNA (cytosine-5)-methyltransferase 3A |
Supplier: | United States Biological |
Supplier-Nr: | D3931-70U |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | 12K80 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant corresponding to aa353-486 from human DNMT3A expressed in E.coli. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K17398 | Matching products |
UniProt ID : | Q9Y6K1 | Matching products |
Gene ID | GeneID 1788 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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