Anti-DHX36

Anti-DHX36
Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-AV6 100 µg - -

6 - 10 business days*

684.00€
 
Anti-DHX36 Antibody was affinity purified from monospecific antiserum by immunoaffinity... more
Product information "Anti-DHX36"
Anti-DHX36 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. At least four isoforms of DDX36 are known to exist, this antibody will detect the three longest isoforms. Protein function: Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation, the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification. [The UniProt Consortium]
Keywords: Anti-G4R1, Anti-DDX36, Anti-DHX36, EC=3.6.4.12, EC=3.6.4.13, Anti-G4-resolvase 1, Anti-MLE-like protein 1, Anti-DEAH box protein 36, Anti-ATP-dependent RNA helicase DHX36, Anti-RNA helicase associated with AU-rich element ARE
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-AV6

Properties

Application: ELISA, IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: 19 amino acid peptide near the C-terminus of human DHX36.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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