Anti-CXCR7 / CD187 (FITC), clone 10D1-J16

Anti-CXCR7 / CD187 (FITC), clone 10D1-J16
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Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
ARG43851.100 100 tests - -

6 - 14 business days*

30 %
624.00€
436.80€
 
Protein function: Atypical chemokine receptor that controls chemokine levels and localization via... more
Product information "Anti-CXCR7 / CD187 (FITC), clone 10D1-J16"
Protein function: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein- mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates. {ECO:0000269, PubMed:16107333, ECO:0000269, PubMed:16940167, ECO:0000269, PubMed:17804806, ECO:0000269, PubMed:18653785, ECO:0000269, PubMed:19255243, ECO:0000269, PubMed:19380869, ECO:0000269, PubMed:19641136, ECO:0000269, PubMed:20018651, ECO:0000269, PubMed:20161793, ECO:0000269, PubMed:20388803, ECO:0000269, PubMed:20887389, ECO:0000269, PubMed:22300987}. [The UniProt Consortium]
Keywords: Anti-ACKR3, Anti-RDC-1, Anti-RDC-1, Anti-CMKOR1, Anti-CXC-R7, Anti-CXCR-7, Anti-CXC-R7, Anti-CXCR-7, Anti-Chemokine orphan receptor 1, Anti-Chemokine orphan receptor 1, Anti-Atypical chemokine receptor 3, Anti-Atypical chemokine receptor 3, Anti-G-protein
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG43851

Properties

Application: FC
Antibody Type: Monoclonal
Clone: 10D1-J16
Conjugate: Fluorescein
Host: Mouse
Species reactivity: human
Immunogen: Human CXCR7 / CD187 fusion protein
MW: 41 kD
Format: Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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