Anti-CRTH2/DP2 Receptor (C-Term)

Prostaglandin D2 (PGD2) elicits its biological function through interaction with two distinct G protein-coupled receptors, DP1 and CRTH2/DP2. CRTH2 primarily couples to Gi or Gq subunits to mobilize Ca2+, induce cell migration, and up-regulate adhesion molecules. CRTH2 mRNA has been detected in various tissues including liver, lung, kidney, brain, heart, thymus, and spleen and in various cell lineages including both hematopoietic and non-hematopoietic cell lines. Human CRTH2 is 395 amino acids in length with an estimated molecular weight of 43 kDa. Cayman's CRTH2/DP2 receptor (C-Term) polyclonal antibody can be used for western blot of CRTH2 on samples of human, mouse, and rat origin. It detects both unglycosylated and glycosylated protein at sizes ranging from 35-40 to 50-70 kDa, as reported by Nagata et al., in 1999.Synonyms: Chemoattractant-receptor Homologous Molecule Expressed on Th2 Cells, DP2 Receptor, GPR44, Prostaglandin D2 Receptor 2. Immunogen: Synthetic peptide from the C-terminal region of human CRTH2/DP2. Formulation: (Request formulation change), 500 µl of peptide affinity-purified polyclonal antibody. Host: Rabbit. Applications: ICC and WB. UniProt Accession #: Q9Y5Y4.