Anti-CrkRS / CDK12 / Cyclin-dependent kinase 12

In 1X PBS, pH 7.4, with 0.09% sodium azide. CrkRS, also known as Cdc2-related kinase, arginine/serine-rich, CDK12 and Cyclin-dependent kinase 12, is a cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. It also regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Protein function: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. [The UniProt Consortium]