Anti-CKI delta

Anti-CKI delta
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-136A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-136A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-136A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Essential serine/threonine-protein kinase that regulates diverse cellular... more
Product information "Anti-CKI delta"
Protein function: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. [The UniProt Consortium]
Keywords: Anti-CKId, Anti-HCKID, Anti-CSNK1D, Anti-CKI-delta, EC=2.7.11.1, EC=2.7.11.26, Anti-Tau-protein kinase CSNK1D, Anti-Casein kinase I isoform delta
Supplier: Bethyl Laboratories
Supplier-Nr: A302-136A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse, Rat, Chicken, Turkey, Bovine, Dog, Horse, Pig, Orangutan, Rhesus Monkey, White-tufted-ear Marmoset, Golden Hamster, Gray Short-tailed Opossum, Small-eared Galago, Zebra Finch)
Immunogen: synthetic peptide. The epitope recognized by A302-136A-T maps to a region between residue 359 and 409 of human casein kinase 1, delta using the numbering given in entry NP_620693.1 (GeneID 1453). This antibody may have slight crossreactivity with CKI epsilon, which has a similar epitope.
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow. more
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-CKI delta"
Write a review
or to review a product.
Viewed