48 products were found matching "K08959"!

Description: CK1-IN-1 (PUN51207) is a casein kinase 1 (CK1) inhibitor. CK1-IN-1 has IC50s of 15 nM, 16 nM, 73 nM for CK1delta, and CK1epsilon, p38sigma MAPK, respectively. Target: Casein Kinase, p38 MAPK. Smiles: Fc1ccc(cc1)-c1nc([nH]c1-c1ccncc1)-c1ccc2ccccc2c1F. References: Filip LACO,et al. 2,4,5-tri-substituted...

Description: LH846 is a selective inhibitor of CK1delta with IC50 values of 290 nM for CK1delta, 1.3 µM for CK1epsilon, and 2.5 µM for CK1alpha, and exhibits no inhibitory activity at CK2. Target: Casein Kinase. Smiles: Cc1cc2sc(NC(=O)Cc3ccccc3)nc2cc1Cl. References: Lee JW, et al. Angew Chem Int Ed Engl. 2011 Nov...

CK1-IN-1 is an inhibitor of casein kinase 1delta (CK1delta) and CK1epsilon (IC50s = 15 and 16 nM, respectively). It is selective for CK1delta and CK1epsilon over TGF-beta receptor type 1 (ALK5, IC50 = 151.8 nM) and TGF-beta receptor type 2 (TGFBR2) at 1 µM.Formal Name:...

Description: PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1epsilon in isolated enzyme preparations. Target: Casein Kinase. Smiles: Cl.Cl.Nc1nccc(n1)-c1c(ncn1C1CCCCC1)-c1ccc(F)cc1. References: Daniel I Perez, et al. Med Res Rev.2011,31(6):...

Description: SR-3029 is a highly potent and specific inhibitor of CK1delta/CK1epsilon. Target: Casein Kinase. Smiles: Fc1cccc(c1)-n1cnc2c(NCc3nc4ccc(F)c(F)c4[nH]3)nc(nc12)N1CCOCC1. References: Rosenberg LH,et al. Therapeutic targeting of casein kinase 1delta in breast cancer. Sci Transl Med. 2015 Dec...

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: CSNK1D. Antigen Species: Human

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: CSNK1D. Antigen Species: Human

Protein function: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic...

SR 3029 is an inhibitor of casein kinase 1delta (CK1delta) and CK1epsilon (IC50s = 44 and 260 nM, respectively). It is selective for CK1delta and CK1epsilon over 438 kinases in a panel but also inhibits MYLK4, FLT3, Cdk4/cyclin D1, and MARK2 by greater than 90% at 10 µM. SR 3029 inhibits Cdk4/cyclin D1, Cdk4/cyclin...

The casein kinase 1 (CK1) family of kinases regulate diverse processes, particularly related to circadian rhythms and sensitivity to amphetamines. PF-670462 is a potent inhibitor of the CK1 isoforms CK1epsilon and CK1delta (IC50 = 7.7 and 14 nM, respectively). It less effectively inhibits a wide variety of related...

Epiblastin A is an ATP-competitive inhibitor of the casein kinase 1 (CK1) isoforms alpha, delta, and epsilon (IC50s = 8.9, 0.5, and 4.7 µM, respectively). It is selective for CK1alpha, CK1delta, and CK1epsilon at concentrations below 10 µM, however, it also inhibits BRSK1, EEF2K, EGFR, MNK-2, and RIPK2 (IC50s =...