Anti-CISH (CIS-1, Protein G18, Suppressor of cytokine signaling)

CISH(cytokine inducible SH2-containing protein),also called CIS, CIS-1, G18, SOCS, is an important , negative regulator for inflammatory signaling and belongs to the suppressors of cytokine signaling , (SOCS) family. CIS family members are known to be cytokine-inducible negative regulators of cytokine , signaling. CISH controls interleukin-2 signaling, and variations of CISH with certain SNPs are , associated with susceptibility to bacteremia, tuberculosis and malaria. The human CISH gene is , mapped to chromosome 3p21.3 by FISH. The mouse gene is tightly linked to the Gnai2 gene on , chromosome 9, a region syntenic to human chromosome 3p21. CIS expression was upregulated by , lipopolysaccharide (LPS) or Cryptosporidium parvum exposure, and this upregulation involved , downregulation of MIR98 and LET7, which relieved MIR98- and LET7-mediated translational repression , of CIS. Gain- and loss-of-function studies showed that CIS accelerated degradation of IKBA and , enhanced NFKB activation in cholangiocytes in response to LPS stimulation or C parvum exposure. UniProt Number: Q9NSE2, Gene ID: CISH, Applications: Suitable for use in Western Blot, Immunohistochemistry (Paraffin) and Immunocytochemistry. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.