Anti-CISH / Cis 1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG58431.50	50 µg		-	-	6 - 14 business days*		551.00€

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Protein function: SOCS family proteins form part of a classical negative feedback system that... more

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Product information "Anti-CISH / Cis 1"

Protein function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. [The UniProt Consortium]

Keywords:	Anti-CIS, Anti-G18, Anti-SOCS, Anti-CISH, Anti-CIS-1, Anti-Protein G18, Anti-Suppressor of cytokine signaling, Anti-Cytokine-inducible SH2-containing protein
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG58431

Properties

Application:	ICC, IF, IHC (paraffin), WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat (Expected: hamster)
Immunogen:	Synthetic peptide corresponding to a sequence at the C-terminus of Human CISH(241-258aa LPLPRRMADYLRQYPFQL), identical to the related Rat and Mouse sequences
MW:	29 kD
Format:	Antigen Affinity Purified