Anti-CHD5

Anti-CHD5
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-92890.60 60 µl -

7 - 16 business days*

198.00€
E-AB-92890.120 120 µl -

7 - 16 business days*

317.00€
E-AB-92890.200 200 µl -

7 - 16 business days*

525.00€
 
This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of... more
Product information "Anti-CHD5"
This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma. Protein function: Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. [The UniProt Consortium]
Keywords: CHD-5, KIAA0444, EC=3.6.4.12, ATP-dependent helicase CHD5, Chromodomain-helicase-DNA-binding protein 5, CHD5 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-92890

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Recombinant fusion protein of human CHD5

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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