Anti-CDK8

Anti-CDK8
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-501A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-501A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-501A 100 µl (20 µg) -

3 - 9 business days*

466.00€
 
Protein function: Component of the Mediator complex, a coactivator involved in regulated gene... more
Product information "Anti-CDK8"
Protein function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. [The UniProt Consortium]
Keywords: Anti-CDK8, EC=2.7.11.22, EC=2.7.11.23, Anti-Protein kinase K35, Anti-Cyclin-dependent kinase 8, Anti-Mediator complex subunit CDK8, Anti-Cell division protein kinase 8, Anti-Mediator of RNA polymerase II transcription subunit CDK8
Supplier: Bethyl Laboratories
Supplier-Nr: A302-501A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse)
Immunogen: synthetic peptide. The epitope recognized by A302-501A-T maps to a region between residue 420 and 470 of human cyclin-dependent kinase 8 using the numbering given in entry NP_001251.1 (GeneID 1024).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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