Anti-CDK4

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-13989.20 20 µl -

7 - 16 business days*

71.00€
E-AB-13989.60 60 µl -

7 - 16 business days*

143.00€
E-AB-13989.120 120 µl -

7 - 16 business days*

238.00€
E-AB-13989.200 200 µl -

7 - 16 business days*

396.00€
 
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein... more
Product information "Anti-CDK4"
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. Protein function: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. [The UniProt Consortium]
Keywords: Anti-CDK4, Anti-PSK-J3, EC=2.7.11.22, Anti-Cyclin-dependent kinase 4, Anti-Cell division protein kinase 4, CDK4 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-13989

Properties

Application: WB, IHC, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Recombinant protein of human CDK4
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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