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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-RQ6165 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. CDK12 cyclin-dependent kinase 12 is a... more
Product information "Anti-CDK12"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. CDK12 cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the CDK12 gene. This enzyme is a member of cyclin-dependent kinase protein family. CDK12 forms protein complexes with cyclin K (CCNK). The CDK12-CCNK complex acts at the level of RNA polymerase II (RNAPII) to regulate expression of long complex genes, several of which have roles in DNA maintenance and repair. Protein function: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. [The UniProt Consortium]
Keywords: | Anti-CRK7, Anti-CDK12, Anti-CrkRS, Anti-hCDK12, EC=2.7.11.23, EC=2.7.11.22, Anti-Cyclin-dependent kinase 12, Anti-CDC2-related protein kinase 7, Anti-Cell division protein kinase 12, Anti-Cdc2-related kinase, arginine/serine-rich, CDK12 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | RQ6165 |
Properties
Application: | WB, IF, FC, Direct ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | A human recombinant partial protein (amino acids Q1147-N1439) |
Format: | Purified |
Database Information
KEGG ID : | K08819 | Matching products |
UniProt ID : | Q9NYV4 | Matching products |
Gene ID | GeneID 51755 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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