Anti-CDK12

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG45194.50	50 µg		-	-	6 - 14 business days*		501.00€

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Protein function: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the... more

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Product information "Anti-CDK12"

Protein function: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. [The UniProt Consortium]

Keywords:	Anti-CRK7, Anti-CDK12, Anti-CrkRS, Anti-CrkRS, Anti-hCDK12, Anti-hCDK12, Anti-Cyclin-dependent kinase 12, Anti-Cyclin-dependent kinase 12, Anti-CDC2-related protein kinase 7, Anti-CDC2-related protein kinase 7, Anti-Cell division protein kinase 12, Anti-C
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG45194

Properties

Application:	FC, ICC, IF, Immunohistochemistry, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant protein containing to human CDK12
MW:	164 kD
Format:	Antigen Affinity Purified