Anti-CDH1

Anti-CDH1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
030075.100 100 µl - -

3 - 19 business days*

477.00€
 
E-Cadherin is a 120kD transmembrane glycoprotein that is localized in the adherens junctions of... more
Product information "Anti-CDH1"
E-Cadherin is a 120kD transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues. Applications: Western Bloting: 1:500-1:2000., ELISA: Suggested dilution 1:10000., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-CDH1, Anti-CDHE
Supplier: United States Biological
Supplier-Nr: 030075

Properties

Application: ELISA, WB
Antibody Type: Monoclonal
Clone: 13B153
Conjugate: No
Host: Mouse
Reactivity: Human, Monkey, Mouse
Immunogen: Purified recombinant fragment of human CDH1 expressed in E. coli.

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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