Anti-CD86, clone C86/1146

Anti-CD86, clone C86/1146
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2988-20UG 20 µg - -

3 - 10 business days

251.00€
NSJ-V2988-100UG 100 µg - -

3 - 10 business days

541.00€
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a protein of 70kDa,... more
Product information "Anti-CD86, clone C86/1146"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a protein of 70kDa, which is identified as CD86. CD86 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. CD86, along with CD80/B71, is an important accessory molecule in T cell co-stimulation via its interaction with CD28 and CD152/CTLA4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. It is also found on malignant Hodgkin and Reed Sternberg (HRS) cells in Hodgkin's disease. Protein function: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. [The UniProt Consortium]
Keywords: Anti-B70, Anti-BU63, Anti-CD86, Anti-FUN-1, Anti-CD28LG2, Anti-Activation B7-2 antigen, Anti-CTLA-4 counter-receptor B7.2, Anti-T-lymphocyte activation antigen CD86, CD86 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V2988-20UG

Properties

Application: FC, IF, WB, IHC (paraffin)
Antibody Type: Monoclonal
Clone: C86/1146
Conjugate: No
Host: Mouse
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant human full-length CD86
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-CD86, clone C86/1146"
Write a review
or to review a product.
Viewed