Anti-CD59, clone 193-27

Anti-CD59, clone 193-27
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3020SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. Reacts with human CD59, a 20kDa glycosyl... more
Product information "Anti-CD59, clone 193-27"
1 mg/ml in sterile PBS, BSA free, sodium azide free. Reacts with human CD59, a 20kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein (Workshop VI, Code N-L036). CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). This mAb recognizes CD59 transfected cells. It is useful for study on GPI-anchored proteins, PNH and CD59 functions. Protein function: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. [The UniProt Consortium]
Keywords: Anti-CD59, Anti-MIRL, Anti-MACIF, Anti-HRF20, Anti-MIC11, Anti-HRF-20, Anti-MAC-IP, Anti-Protectin, Anti-1F5 antigen, Anti-MEM43 antigen, Anti-CD59 glycoprotein, Anti-MAC-inhibitory protein, Anti-Membrane inhibitor of reactive lysis, CD59 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V3020SAF-100UG

Properties

Application: FA (activity), FC, IF
Antibody Type: Monoclonal
Clone: 193-27
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Stimulated human leukocytes
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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