Anti-CD44v6, clone CD44v6/1246

Anti-CD44v6, clone CD44v6/1246
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3284-20UG 20 µg - -

3 - 10 business days

251.00€
NSJ-V3284-100UG 100 µg - -

3 - 10 business days

541.00€
 
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. This antibody... more
Product information "Anti-CD44v6, clone CD44v6/1246"
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. This antibody recognizes an epitope encoded by exon v6 on the variant portion of human CD44. The CD44 molecule belongs to a family of cellular adhesion molecules found on a wide range of normal and malignant cells in epithelial, mesothelial and hemopoiesis tissues. CD44 is a single gene with 20 exons, of which 10 are normally expressed to encode the basic CD44 (H-CAM) molecule. The additional 10 exons (v1 to v10) are only expressed by alternative splicing of the nuclear RNA. The expression of specific cell adhesion molecule CD44 splice variants has been reported to be associated with metastasis in certain human malignancies. Protein function: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9, the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function. [The UniProt Consortium]
Keywords: Anti-LHR, Anti-CD44, Anti-PGP-1, Anti-CDw44, Anti-PGP-I, Anti-Epican, Anti-HUTCH-I, Anti-ECMR-III, Anti-CD44 antigen, Anti-Hermes antigen, Anti-Hyaluronate receptor, Anti-Phagocytic glycoprotein 1, Anti-Phagocytic glycoprotein I, CD44v6 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V3284-20UG

Properties

Application: FC, IF, IHC (paraffin)
Antibody Type: Monoclonal
Clone: CD44v6/1246
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: An amino acid sequence from the variant 6 domain of CD44 was used as the immunogen for the CD44v6 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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