Anti-CD43, clone SPN/1094

Anti-CD43, clone SPN/1094
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2874-20UG 20 µg - -

3 - 10 business days

251.00€
NSJ-V2874-100UG 100 µg - -

3 - 10 business days

541.00€
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. It recognizes a cell surface... more
Product information "Anti-CD43, clone SPN/1094"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. It recognizes a cell surface glycoprotein of 95/115/135kDa (depending upon the extent of glycosylation), identified as CD43. 70-90% of T-cell lymphomas and from 22-37% of B-cell lymphomas express CD43. No reactivity has been observed with reactive B-cells. So a B-lineage population that co-expresses CD43 is highly likely to be a malignant lymphoma, especially a low-grade lymphoma, rather than a reactive B-cell population. When CD43 antibody is used in combination with anti-CD20, effective immunophenotyping of the lymphomas in formalin-fixed tissues can be obtained. Co-staining of a lymphoid infiltrate with anti-CD20 and anti-CD43 argues against a reactive process and favors a diagnosis of lymphoma. Protein function: One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1. During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response. [The UniProt Consortium]
Keywords: Anti-SPN, Anti-CD43, Anti-GALGP, Anti-Sialophorin, Anti-Leukosialin, Anti-Galactoglycoprotein, Anti-Leukocyte sialoglycoprotein, CD43 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V2874-20UG

Properties

Application: FC, IF, IHC (paraffin)
Antibody Type: Monoclonal
Clone: SPN/1094
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Recombinant human SPN/CD43 protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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