Anti-CD3 (Clone: OKT3) (NALE(TM) No Azide Low Endotoxin)

Anti-CD3 (Clone: OKT3) (NALE(TM) No Azide Low Endotoxin)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-10-4089-NALE-100 100 µg -

3 - 11 business days*

205.00€
 
CD3 is one of the several invariant chains that the variable chains of TCR: Alpha beta or Gamma... more
Product information "Anti-CD3 (Clone: OKT3) (NALE(TM) No Azide Low Endotoxin)"
CD3 is one of the several invariant chains that the variable chains of TCR: Alpha beta or Gamma delta TCR contains, and which support surface TCR expression and transduce the TCR signal. CD3D, along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Protein function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells(PubMed:12215456). [The UniProt Consortium]
Keywords: Anti-T3D, Anti-CD3D, Anti-CD3d, Anti-T-cell receptor T3 delta chain, Anti-T-cell surface glycoprotein CD3 delta chain, Monoclonal Antibody to CD3 (Clone: OKT3) (No Azide Low Endotoxin)
Supplier: Abeomics
Supplier-Nr: 10-4089-NALE

Properties

Application: FC
Antibody Type: Monoclonal
Clone: OKT3
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Human PBMCs were used as immunogen for the CD3 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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