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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-30-1769-100 | 100 tests | - |
3 - 11 business days* |
713.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD229 (Ly9) is a cell surface receptor of the CD150 family, which includes also e.g. CD48 and... more
Product information "Anti-CD229 / Ly9 Monoclonal Antibody (Clone:HLy9.25)-APC Conjugated"
CD229 (Ly9) is a cell surface receptor of the CD150 family, which includes also e.g. CD48 and CD224. Receptors of this family regulate cytokine production and cytotoxicity of lymphocytes and NK cells. High levels of CD229 are found on T and B cells, where its expression increases during their maturation. It is absent on granulocytes, bone marrow-derived dendritic cells, platelets and erythrocytes. CD229 has been also reported on mouse monocytes and NK cells. CD229 interacts homophilically through its N-terminal domain and localizes to the contact site between T cells and antigen presenting B cells during antigen-dependent immune synapse formation. Protein function: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion, the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells. [The UniProt Consortium]
Keywords: | Anti-LY9, Anti-CD229, Anti-SLAMF3, Anti-CDABP0070, Anti-Lymphocyte antigen 9, Anti-SLAM family member 3, Anti-Cell surface molecule Ly-9, Anti-T-lymphocyte surface antigen Ly-9, Anti-Signaling lymphocytic activation molecule 3, Anti-CD229 / Ly9 Monoclonal |
Supplier: | Abeomics |
Supplier-Nr: | 30-1769 |
Properties
Application: | FC, IP, WB, ICC, FA |
Antibody Type: | Monoclonal |
Clone: | HLy9.25 |
Conjugate: | APC |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | CD299-transfected 300.19 pre-B cell line |
Database Information
KEGG ID : | K06570 | Matching products |
UniProt ID : | Q9HBG7 | Matching products |
Gene ID : | GeneID 4063 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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-30 %
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