Anti-CD155 (PVR) (human), clone ANC6A3 (preservative free)

Monoclonal Antibody. Binds to human cell surface CD155 on U-937 cells, and binds to recombinant human CD155 in EIA. Applications: ELISA, FACS. Isotype: Mouse IgG1kappa. Clone: ANC6A3. Liquid. 50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl. Human CD155 (Polio Virus Receptor, PVR, Necl-5) is a 70 kd type I Ig superfamily molecule. It is involved in formation of intracellular junctions between epithelial cells. Its ligands include CD226 (DNAM-1), and CD96 (TACTILE). CD155 expression by tumor has been shown to be upregulated by nitric oxide. A soluble version of CD155 has been shown to exist. High CD155 expression has recently been exploited to use engineered poliovirus to treat glioblastoma.