Anti-CD112 (human), Azide Free Clone B-C12 [Mouse]

Specificity: Recognises Nectin-2, the polio retrovirus receptor-2 (PRR2), Format: Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free, Storage: Stable at +2-8°C for 12 months. For longer storage, freeze aliquots, Application Notes: Suitable for flow cytometry. Suitable for immunohistochemistry (recommended dilution 1:50) Protein function: Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). [The UniProt Consortium]