Anti-CD10 / Neprilysin, clone MME/12957R

0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide. MME/CD10 Antibody recognizes Membrane metalloendopeptidase, also known as CD10, Neprilysin, and neutral endopeptidase, a zinc-dependent cell surface metalloprotease encoded by the MME gene. MME/CD10 antibody targets a type II transmembrane glycoprotein that functions as an important regulator of bioactive peptide signaling in multiple tissues. CD10 was originally identified as the common acute lymphoblastic leukemia antigen (CALLA) and remains widely used as a diagnostic marker in hematopathology and surgical pathology.Membrane metalloendopeptidase is localized predominantly to the plasma membrane, where it enzymatically cleaves and inactivates a variety of biologically active peptides, including enkephalins, natriuretic peptides, substance P, and bradykinin. Through this proteolytic activity, CD10 plays a key role in modulating inflammatory responses, blood pressure regulation, and neuropeptide signaling. In normal tissues, MME expression is observed in renal proximal tubular epithelium, certain lymphoid precursors, endometrial stromal cells, and subsets of epithelial cells in multiple organs.In diagnostic pathology, MME/CD10 antibody is frequently used to characterize hematologic malignancies and epithelial tumors. CD10 expression is classically associated with precursor B-cell acute lymphoblastic leukemia and certain germinal center B-cell lymphomas. In solid tumors, CD10 is commonly expressed in renal cell carcinoma, endometrial stromal tumors, and subsets of prostate and breast carcinomas. Membranous staining is typically observed, reflecting the cell surface localization of the protein, although cytoplasmic accentuation may also be present depending on tissue context and fixation conditions.At the molecular level, Membrane metalloendopeptidase belongs to the neprilysin family of metalloproteases and contains a large extracellular catalytic domain with a zinc-binding motif essential for enzymatic activity. Altered MME expression has been linked to tumor progression, stromal remodeling, and changes in peptide-mediated signaling pathways within the tumor microenvironment. Dysregulation of CD10 may influence cell proliferation, apoptosis, and local immune responses.MME/CD10 Antibody provides a reliable tool for detecting CD10 expression in research and pathology applications. Clone MME/12957R is designed to identify membranous MME/CD10 expression patterns, supporting studies of hematologic neoplasms, renal pathology, and peptide regulatory mechanisms in normal and neoplastic tissues.